Detailed information of TA system TA197683

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 3048972..3049631
• Replicon: chromosome
• Accession: NZ_CP072386
• Organism: Arachnia propionica strain F0231

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: J5A61_RS13675
• Protein ID: WP_244926088.1
• Coordinates: 3048972..3049283 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A448N254
• Locus tag: J5A61_RS13680
• Protein ID: WP_073970044.1
• Coordinates: 3049383..3049631 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J5A61_RS13650 (J5A61_13650)	3044579..3045235	-	657	WP_014847806.1	response regulator transcription factor	-
J5A61_RS13655 (J5A61_13655)	3045229..3046416	-	1188	WP_014847807.1	histidine kinase	-
J5A61_RS13660 (J5A61_13660)	3046546..3047268	+	723	WP_061787614.1	ATP-binding cassette domain-containing protein	-
J5A61_RS13665 (J5A61_13665)	3047265..3048047	+	783	WP_061787613.1	ABC transporter permease	-
J5A61_RS13670 (J5A61_13670)	3048194..3048706	-	513	WP_061787612.1	lincomycin resistance protein LmrB	-
J5A61_RS13675 (J5A61_13675)	3048972..3049283	-	312	WP_244926088.1	hypothetical protein	Toxin
J5A61_RS13680 (J5A61_13680)	3049383..3049631	-	249	WP_073970044.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
J5A61_RS13685 (J5A61_13685)	3049900..3050139	+	240	WP_061787610.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
J5A61_RS13690 (J5A61_13690)	3050139..3050498	+	360	WP_061787609.1	type II toxin-antitoxin system VapC family toxin	-
J5A61_RS13695 (J5A61_13695)	3050737..3052692	+	1956	WP_211798447.1	class I SAM-dependent DNA methyltransferase	-
J5A61_RS13700 (J5A61_13700)	3052689..3053918	+	1230	WP_073970031.1	restriction endonuclease subunit S	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (4-101)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-42)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 11421.20 Da
• Isoelectric Point: 10.1031

>T197683 WP_244926088.1 NZ_CP072386:c3049283-3048972 [Arachnia propionica]
VSELILSGFLRIVTNHRVYREPTSPQVALDFCQTVLSASSAVRIRPGRGHWRIFESLCRNLGARGNVVPDAYLAAMAIEA
DATFITMDAGFARFPGLTWRRAL

Nucleotide

• Length: 312 bp

>T197683 NZ_CP096574:c3001637-3001341 [Geomonas paludis]
ATGTACATCGTCAAGACCCTTCCCGAATTTGACGCTTGGCTAAATGGCATCAAAGACCGCACCACTCGGTTGCGGCTGGC
TCGACGCCTTGACAAGGCCCAGCGAGGCGATCTCGGTGATGTGAAATCCGTTGGCCACGGCGTTTTTGAGATGCGTGAGT
TCTTTGGCTCCGGCTGGCGAATGTACTACATTGAACGTGGCAACATGCTTATCGTGATGCTCGGCGGTGGGGACAAATCC
ACACAAACAGCCGACATTGCCATTGCCTTCGAGCGGGCAGCCAGATTGGAGGATTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8872.98 Da
• Isoelectric Point: 5.1599

>AT197683 WP_073970044.1 NZ_CP072386:c3049631-3049383 [Arachnia propionica]
MRTTVNLDDELLRRAKERAARQGRTLSEVVSDALRVSLAEQAGPRREVTLPTFGGSGLKPGVDLEDKDALAALLGEDDRA
AR

Nucleotide

• Length: 249 bp

>AT197683 NZ_CP096574:c3001337-3001035 [Geomonas paludis]
ATGCCGAAAAAAATCGTTGTATCGGACCTCTCGGAATTTGATCTTGCCACCCAGTTAAAAAGCGAGGCCGACATTGCGGC
GTATATCACCATGGTGATTGAGGATGGTGACGCAGCAGAGTTGGCCCATGCCTTAGGAGTCGCCGCACGAGCGCGCGGCA
TGGCTGAAATTGCTCAGGCTGCCGGGCTGACACGCGAAGCCCTCTACAAAGCCTTGCGTCCCGGAGCTCATCCACGCTTC
GACACAATCAGCCGAGTTTGTTCCGCGCTTGGAGTCCGCTTGGTTGCTCAGCCTCGCCATTAG

Structures

Antitoxin

• AlphaFold DB: A0A448N254