Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-YefM
Location 2778708..2779215 Replicon chromosome
Accession NZ_CP072386
Organism Arachnia propionica strain F0231

Toxin (Protein)


Gene name relE Uniprot ID A0A3S4Y8S1
Locus tag J5A61_RS12575 Protein ID WP_061788152.1
Coordinates 2778708..2778962 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A3N4D924
Locus tag J5A61_RS12580 Protein ID WP_014847591.1
Coordinates 2778964..2779215 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J5A61_RS12555 (J5A61_12555) 2774241..2774714 - 474 WP_014847587.1 GNAT family N-acetyltransferase -
J5A61_RS12560 (J5A61_12560) 2774818..2776221 - 1404 WP_211798356.1 DHA2 family efflux MFS transporter permease subunit -
J5A61_RS12565 (J5A61_12565) 2776290..2777114 + 825 WP_211798357.1 class I SAM-dependent methyltransferase -
J5A61_RS12570 (J5A61_12570) 2777555..2778649 + 1095 WP_211798358.1 Fic family protein -
J5A61_RS12575 (J5A61_12575) 2778708..2778962 - 255 WP_061788152.1 Txe/YoeB family addiction module toxin Toxin
J5A61_RS12580 (J5A61_12580) 2778964..2779215 - 252 WP_014847591.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
J5A61_RS12585 (J5A61_12585) 2779393..2779977 - 585 WP_014847592.1 TetR/AcrR family transcriptional regulator -
J5A61_RS12590 (J5A61_12590) 2780048..2781277 + 1230 WP_061788153.1 MFS transporter -
J5A61_RS12595 (J5A61_12595) 2781264..2782217 - 954 WP_211798359.1 NmrA/HSCARG family protein -
J5A61_RS12600 (J5A61_12600) 2782339..2782722 + 384 WP_014847595.1 helix-turn-helix domain-containing protein -
J5A61_RS12605 (J5A61_12605) 2782798..2783832 + 1035 WP_061788154.1 DUF2330 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-69)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9762.01 Da        Isoelectric Point: 6.4548

>T197682 WP_061788152.1 NZ_CP072386:c2778962-2778708 [Arachnia propionica]
VRLAWDPSAWEDYTYWQAADSRILKRINALIDTCLRDPSGGIGKPEQLRYGAPGAWSRRITEEHRLVYLVDGDDLVILQA
RYHY

Download         Length: 255 bp

>T197682 NZ_CP096574:c3001337-3001035 [Geomonas paludis]
ATGCCGAAAAAAATCGTTGTATCGGACCTCTCGGAATTTGATCTTGCCACCCAGTTAAAAAGCGAGGCCGACATTGCGGC
GTATATCACCATGGTGATTGAGGATGGTGACGCAGCAGAGTTGGCCCATGCCTTAGGAGTCGCCGCACGAGCGCGCGGCA
TGGCTGAAATTGCTCAGGCTGCCGGGCTGACACGCGAAGCCCTCTACAAAGCCTTGCGTCCCGGAGCTCATCCACGCTTC
GACACAATCAGCCGAGTTTGTTCCGCGCTTGGAGTCCGCTTGGTTGCTCAGCCTCGCCATTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9497.50 Da        Isoelectric Point: 4.6794

>AT197682 WP_014847591.1 NZ_CP072386:c2779215-2778964 [Arachnia propionica]
VSISASEARRTLFPLIEQVNDDRTAVEIVSRKGNAVLMSADEYAAWQETAYLFRSPANARRLLDAYERAREGRSEEHDLI
RED

Download         Length: 252 bp

>AT197682 NZ_CP096574:c3001637-3001341 [Geomonas paludis]
ATGTACATCGTCAAGACCCTTCCCGAATTTGACGCTTGGCTAAATGGCATCAAAGACCGCACCACTCGGTTGCGGCTGGC
TCGACGCCTTGACAAGGCCCAGCGAGGCGATCTCGGTGATGTGAAATCCGTTGGCCACGGCGTTTTTGAGATGCGTGAGT
TCTTTGGCTCCGGCTGGCGAATGTACTACATTGAACGTGGCAACATGCTTATCGTGATGCTCGGCGGTGGGGACAAATCC
ACACAAACAGCCGACATTGCCATTGCCTTCGAGCGGGCAGCCAGATTGGAGGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S4Y8S1

Antitoxin

Source ID Structure
AlphaFold DB A0A3N4D924

References