Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 2734444..2735009 Replicon chromosome
Accession NZ_CP072386
Organism Arachnia propionica strain F0231

Toxin (Protein)


Gene name vapC Uniprot ID A0A3N4CZH7
Locus tag J5A61_RS12375 Protein ID WP_014847549.1
Coordinates 2734444..2734806 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A3N4D1U3
Locus tag J5A61_RS12380 Protein ID WP_014847550.1
Coordinates 2734803..2735009 (-) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J5A61_RS12345 (J5A61_12345) 2729556..2729825 + 270 WP_014847541.1 zinc ribbon domain-containing protein -
J5A61_RS12350 (J5A61_12350) 2729894..2730508 + 615 WP_211798348.1 SAF domain-containing protein -
J5A61_RS12355 (J5A61_12355) 2730801..2731160 + 360 WP_126380524.1 large conductance mechanosensitive channel protein MscL -
J5A61_RS12360 (J5A61_12360) 2731208..2731552 - 345 WP_061788127.1 hypothetical protein -
J5A61_RS12365 (J5A61_12365) 2731555..2732931 - 1377 WP_211798349.1 UTP--glucose-1-phosphate uridylyltransferase -
J5A61_RS12370 (J5A61_12370) 2733325..2734038 + 714 WP_244926082.1 hypothetical protein -
J5A61_RS12375 (J5A61_12375) 2734444..2734806 - 363 WP_014847549.1 type II toxin-antitoxin system VapC family toxin Toxin
J5A61_RS12380 (J5A61_12380) 2734803..2735009 - 207 WP_014847550.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
J5A61_RS12385 (J5A61_12385) 2735187..2735750 - 564 WP_159424567.1 TetR family transcriptional regulator C-terminal domain-containing protein -
J5A61_RS12390 (J5A61_12390) 2735816..2736832 + 1017 WP_244926083.1 alpha/beta hydrolase -
J5A61_RS12395 (J5A61_12395) 2736842..2737882 - 1041 WP_061788132.1 glycoside hydrolase family 76 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13682.99 Da        Isoelectric Point: 7.9144

>T197681 WP_014847549.1 NZ_CP072386:c2734806-2734444 [Arachnia propionica]
VILVDTSVWIDHFRRSDLRLVRLLRGDEAGCHAMVIGELSLSSMPARTVRMSYLSNLYRFPSLHDDELLHLVETRRLWGR
GLSLVDVNLIGSVLVVPGACLWTRDKRLRAVAKELEIAFE

Download         Length: 363 bp

>T197681 NZ_CP096574:c2205936-2205685 [Geomonas paludis]
ATGAATACAATTACTTACAGCTCAGCCCGCAGCAACCTTGCTGAAACGATGGAGAAAGTATGTGACGACCATGCCCCGGT
AATCATCACCCGGAAAGCTGCTAAACCAGTCGTCATGATGTCGCTGGACGACTATGAGGCACTTGAAGAAACGGCGTACC
TGCTCAGAAGCCCAAAGAACGTGCGCCGCCTGATGGAATCTGTCGCCGAATTGGAAGCAGGCAAAGGACGCGAAAGGGAG
CTTGTCGAGTGA

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7449.47 Da        Isoelectric Point: 5.0807

>AT197681 WP_014847550.1 NZ_CP072386:c2735009-2734803 [Arachnia propionica]
MRTTVTLDDDLVARAQELTGVKERSVLLREGLETLIRVESARRLAALGGTEPEAQISSRTRDLGDLAK

Download         Length: 207 bp

>AT197681 NZ_CP096574:c2205688-2205434 [Geomonas paludis]
GTGAAGCTGATCTTCTCGGAATTTGCTTGGGAAGATTATCTGCACTGGCAAAGCGCGGATAAAAAGATATTGAAGCGTAT
CAACACACTCATCAGGGAAATCCAAAGAACGCCTTATCAAGGGATAGGCAAGCCAGAACCTTTGAAGCACGCCTTGTCAG
GCTTTTGGTCTCGCAGAATCAACGATGAACACCGCATCGTCTACAAAGTTGATGATGACGCCGTCCTGATCGCTCAGCTT
CGCTACCACTACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3N4CZH7

Antitoxin

Source ID Structure
AlphaFold DB A0A3N4D1U3

References