Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC(toxin) |
| Location | 2425362..2426005 | Replicon | chromosome |
| Accession | NZ_CP072386 | ||
| Organism | Arachnia propionica strain F0231 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | A0A448N0K5 |
| Locus tag | J5A61_RS10905 | Protein ID | WP_061788423.1 |
| Coordinates | 2425604..2426005 (+) | Length | 134 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | A0A4P8ZS27 |
| Locus tag | J5A61_RS10900 | Protein ID | WP_014847289.1 |
| Coordinates | 2425362..2425607 (+) | Length | 82 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J5A61_RS10870 (J5A61_10870) | 2421205..2422173 | - | 969 | WP_211798230.1 | WYL domain-containing protein | - |
| J5A61_RS10875 (J5A61_10875) | 2422272..2422655 | + | 384 | WP_211798231.1 | VOC family protein | - |
| J5A61_RS10880 (J5A61_10880) | 2422797..2424057 | + | 1261 | Protein_2148 | ATP-binding protein | - |
| J5A61_RS10885 (J5A61_10885) | 2424429..2424596 | - | 168 | WP_014847286.1 | 50S ribosomal protein L33 | - |
| J5A61_RS10890 (J5A61_10890) | 2424598..2424834 | - | 237 | WP_014847287.1 | 50S ribosomal protein L28 | - |
| J5A61_RS10895 (J5A61_10895) | 2424919..2425167 | + | 249 | WP_041697718.1 | type B 50S ribosomal protein L31 | - |
| J5A61_RS10900 (J5A61_10900) | 2425362..2425607 | + | 246 | WP_014847289.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| J5A61_RS10905 (J5A61_10905) | 2425604..2426005 | + | 402 | WP_061788423.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| J5A61_RS10910 (J5A61_10910) | 2426091..2426789 | - | 699 | WP_061788422.1 | 50S ribosomal protein L1 | - |
| J5A61_RS10915 (J5A61_10915) | 2426873..2427301 | - | 429 | WP_014847292.1 | 50S ribosomal protein L11 | - |
| J5A61_RS10920 (J5A61_10920) | 2427398..2428183 | - | 786 | WP_061788421.1 | transcription termination/antitermination protein NusG | - |
| J5A61_RS15525 | 2428180..2428356 | - | 177 | Protein_2157 | preprotein translocase subunit SecE | - |
| J5A61_RS10935 (J5A61_10935) | 2428901..2429923 | - | 1023 | WP_061788420.1 | UDP-N-acetylmuramate dehydrogenase | - |
| J5A61_RS10940 (J5A61_10940) | 2429916..2430329 | - | 414 | WP_014847296.1 | MaoC/PaaZ C-terminal domain-containing protein | - |
| J5A61_RS10945 (J5A61_10945) | 2430322..2430750 | - | 429 | WP_014847297.1 | MaoC family dehydratase N-terminal domain-containing protein | - |
| J5A61_RS10950 (J5A61_10950) | 2430821..2430991 | - | 171 | WP_014847298.1 | 50S ribosomal protein L33 | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 134 a.a. Molecular weight: 13933.99 Da Isoelectric Point: 6.2177
>T197680 WP_061788423.1 NZ_CP072386:2425604-2426005 [Arachnia propionica]
MIVAPSAIAAILLKEPESSGFRELLGRRGGQLSAPGYLELSIVLTARGVTDPVATLDAILLGLGVEVVPFTPSQARLAQE
AHLRFGRGSGHPARLNFGDCISYALAKDTGEPLLFKGNDFVHTDLNPASGISP
MIVAPSAIAAILLKEPESSGFRELLGRRGGQLSAPGYLELSIVLTARGVTDPVATLDAILLGLGVEVVPFTPSQARLAQE
AHLRFGRGSGHPARLNFGDCISYALAKDTGEPLLFKGNDFVHTDLNPASGISP
Download Length: 402 bp
>T197680 NZ_CP072386:2425604-2426005 [Arachnia propionica]
ATGATCGTCGCCCCGTCTGCGATTGCCGCCATCCTGCTGAAGGAGCCGGAGAGCAGCGGCTTCCGTGAGCTGCTGGGCAG
GCGTGGCGGCCAATTGTCCGCCCCCGGTTACCTGGAGTTGTCGATCGTGCTCACGGCGCGGGGAGTCACCGACCCAGTCG
CCACCCTCGATGCGATCCTGCTCGGCCTCGGCGTGGAGGTGGTGCCTTTCACGCCGTCACAGGCTCGCCTGGCTCAGGAG
GCCCACCTGCGTTTCGGCAGGGGCAGCGGCCATCCGGCCAGGCTGAACTTCGGTGACTGCATCAGCTACGCCCTCGCCAA
GGACACCGGGGAACCCCTTTTGTTCAAGGGAAACGACTTCGTCCACACCGATCTGAACCCCGCCTCCGGGATCTCACCCT
GA
ATGATCGTCGCCCCGTCTGCGATTGCCGCCATCCTGCTGAAGGAGCCGGAGAGCAGCGGCTTCCGTGAGCTGCTGGGCAG
GCGTGGCGGCCAATTGTCCGCCCCCGGTTACCTGGAGTTGTCGATCGTGCTCACGGCGCGGGGAGTCACCGACCCAGTCG
CCACCCTCGATGCGATCCTGCTCGGCCTCGGCGTGGAGGTGGTGCCTTTCACGCCGTCACAGGCTCGCCTGGCTCAGGAG
GCCCACCTGCGTTTCGGCAGGGGCAGCGGCCATCCGGCCAGGCTGAACTTCGGTGACTGCATCAGCTACGCCCTCGCCAA
GGACACCGGGGAACCCCTTTTGTTCAAGGGAAACGACTTCGTCCACACCGATCTGAACCCCGCCTCCGGGATCTCACCCT
GA
Antitoxin
Download Length: 82 a.a. Molecular weight: 8705.75 Da Isoelectric Point: 4.5816
>AT197680 WP_014847289.1 NZ_CP072386:2425362-2425607 [Arachnia propionica]
VSLNIKDEHIHDLVRRAATRTGLSQTRVVERAVVELLASLEAEAAASGLDQLLDRVHAELTASGGALDFDALYDPETGLP
R
VSLNIKDEHIHDLVRRAATRTGLSQTRVVERAVVELLASLEAEAAASGLDQLLDRVHAELTASGGALDFDALYDPETGLP
R
Download Length: 246 bp
>AT197680 NZ_CP072386:2425362-2425607 [Arachnia propionica]
GTGAGTTTGAACATCAAGGACGAGCACATCCACGACCTGGTCCGTCGGGCCGCCACCCGGACGGGGCTGAGTCAGACCCG
CGTGGTCGAACGGGCCGTGGTTGAGCTGCTGGCCTCCCTGGAAGCGGAAGCCGCCGCCTCCGGTCTCGATCAGCTCTTGG
ACCGGGTGCATGCCGAGCTCACGGCCTCCGGCGGCGCCCTGGACTTCGACGCCCTCTACGACCCCGAGACGGGGTTGCCG
CGATGA
GTGAGTTTGAACATCAAGGACGAGCACATCCACGACCTGGTCCGTCGGGCCGCCACCCGGACGGGGCTGAGTCAGACCCG
CGTGGTCGAACGGGCCGTGGTTGAGCTGCTGGCCTCCCTGGAAGCGGAAGCCGCCGCCTCCGGTCTCGATCAGCTCTTGG
ACCGGGTGCATGCCGAGCTCACGGCCTCCGGCGGCGCCCTGGACTTCGACGCCCTCTACGACCCCGAGACGGGGTTGCCG
CGATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A448N0K5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A4P8ZS27 |