Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2132662..2133122 Replicon chromosome
Accession NZ_CP072386
Organism Arachnia propionica strain F0231

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag J5A61_RS09435 Protein ID WP_281412298.1
Coordinates 2132662..2132895 (-) Length 78 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag J5A61_RS09440 Protein ID WP_095532222.1
Coordinates 2132895..2133122 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J5A61_RS09415 (J5A61_09415) 2128054..2130357 + 2304 WP_211798127.1 TIGR03986 family CRISPR-associated RAMP protein -
J5A61_RS09420 (J5A61_09420) 2130592..2130819 + 228 Protein_1860 ISL3 family transposase -
J5A61_RS09425 (J5A61_09425) 2131173..2132252 + 1080 WP_246487161.1 IS630 family transposase -
J5A61_RS09430 (J5A61_09430) 2132452..2132640 + 189 WP_211799235.1 hypothetical protein -
J5A61_RS09435 (J5A61_09435) 2132662..2132895 - 234 WP_281412298.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
J5A61_RS09440 (J5A61_09440) 2132895..2133122 - 228 WP_095532222.1 ribbon-helix-helix domain-containing protein Antitoxin
J5A61_RS09445 (J5A61_09445) 2133260..2136109 - 2850 WP_246487162.1 vitamin B12-dependent ribonucleotide reductase -
J5A61_RS09450 (J5A61_09450) 2136147..2136683 - 537 WP_014846985.1 transcriptional regulator NrdR -
J5A61_RS09455 (J5A61_09455) 2136882..2137211 - 330 WP_211798129.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-67)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-40)


Sequences

Toxin        


Download         Length: 78 a.a.        Molecular weight: 8277.57 Da        Isoelectric Point: 11.6533

>T197679 WP_281412298.1 NZ_CP072386:c2132895-2132662 [Arachnia propionica]
VLRGEIRLVDLEPARAGEADKRRPAIIVSNNRANTVAARLGRGVVTVVPVTSNTARVFPFQVLLTADEVGIRLDSKA

Download         Length: 234 bp

>T197679 NZ_CP096574:c254042-253698 [Geomonas paludis]
ATGACAGCGGCGGGTTACGTTCCCGACAGAGGAGAGGTGGTATGGCTTGATTTCGATCCTCAGGCGGGCCACGAGCATGC
CGGCCGACGCCCAGCTTTCGTGCTGTCGCCGCGCAACTACAATAAGAAAACCAGCCTCATGCTCTGCTGCCCAATCACCT
CGCAGGTAAAGGGCTACCCGTTCGAGGTGGCAGTTGCTGGAGTTACCACTGTCCGGGGTGTCATATTGGCCGACCAGGTG
AAATCGTTGGACTGGCAAGTACGACGAGCAGAGAAAGGCGGCAGGGCTAGTAGGGGAGTGCTCGAAGAAGTCATCCTAAA
GGTTCGCGCCATTCTCGAAGGATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 7907.80 Da        Isoelectric Point: 4.0390

>AT197679 WP_095532222.1 NZ_CP072386:c2133122-2132895 [Arachnia propionica]
MGQVKLSVSLSPSEVAVLDKYAQSAGLKSRSAAIQQAIKLLGDPDLEDAYTAAWQEWEDAGEAEAWAATVADGVK

Download         Length: 228 bp

>AT197679 NZ_CP096574:c254281-254039 [Geomonas paludis]
ATGGTAGCGAAAGCTCAAAAATGGGGCAACAGCCTGGCAGTGCGCTTGCCGAAGTCAATAGCGGCAGAGTGTGGTATCGA
AGCGGAGTCGCCGGTAGAGATCACCAGGCAGGAGGGGTACATAGTCATCAAGCCCATCGTTAACAAGGTTCTTTCGCTGG
ACGCCCTCCTCGATGGAATCAACGAGGAAAACCTGCATGCCGAGGTTAGTTGCGGAAAACCAGTTGGCAGGGAATTGCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References