Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 968618..969261 Replicon chromosome
Accession NZ_CP072385
Organism Arachnia propionica strain F0714

Toxin (Protein)


Gene name vapC Uniprot ID A0A4P8ZRW0
Locus tag J5A53_RS04365 Protein ID WP_014847290.1
Coordinates 968618..969019 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A4P8ZS27
Locus tag J5A53_RS04370 Protein ID WP_014847289.1
Coordinates 969016..969261 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J5A53_RS04320 (J5A53_04320) 963632..963802 + 171 WP_014847298.1 50S ribosomal protein L33 -
J5A53_RS04325 (J5A53_04325) 963873..964301 + 429 WP_014847297.1 MaoC family dehydratase N-terminal domain-containing protein -
J5A53_RS04330 (J5A53_04330) 964294..964707 + 414 WP_014847296.1 MaoC/PaaZ C-terminal domain-containing protein -
J5A53_RS04335 (J5A53_04335) 964700..965722 + 1023 WP_014847295.1 UDP-N-acetylmuramate dehydrogenase -
J5A53_RS15595 966267..966443 + 177 Protein_851 preprotein translocase subunit SecE -
J5A53_RS04350 (J5A53_04350) 966440..967225 + 786 WP_014847293.1 transcription termination/antitermination protein NusG -
J5A53_RS04355 (J5A53_04355) 967322..967750 + 429 WP_014847292.1 50S ribosomal protein L11 -
J5A53_RS04360 (J5A53_04360) 967834..968532 + 699 WP_014847291.1 50S ribosomal protein L1 -
J5A53_RS04365 (J5A53_04365) 968618..969019 - 402 WP_014847290.1 type II toxin-antitoxin system VapC family toxin Toxin
J5A53_RS04370 (J5A53_04370) 969016..969261 - 246 WP_014847289.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
J5A53_RS04375 (J5A53_04375) 969456..969704 - 249 WP_041697718.1 type B 50S ribosomal protein L31 -
J5A53_RS04380 (J5A53_04380) 969789..970025 + 237 WP_014847287.1 50S ribosomal protein L28 -
J5A53_RS04385 (J5A53_04385) 970027..970194 + 168 WP_014847286.1 50S ribosomal protein L33 -
J5A53_RS04390 (J5A53_04390) 970566..971819 - 1254 WP_041696623.1 ATP-binding protein -
J5A53_RS04395 (J5A53_04395) 971967..972350 - 384 WP_014847284.1 VOC family protein -
J5A53_RS04400 (J5A53_04400) 972449..973417 + 969 WP_014847283.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(2-76)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13978.00 Da        Isoelectric Point: 5.6079

>T197676 WP_014847290.1 NZ_CP072385:c969019-968618 [Arachnia propionica]
MIVDPSAIAAILLKEPESSGFRELLGRRGGQLSAPGYLELSIVLTARGVTDPVATLDAILLGLGVEVVPFTPSQARLAQE
AHLRFGRGSGHPARLNFGDCISYALAKDTGEPLLFKGNDFVHTDLNPASGISP

Download         Length: 402 bp

>T197676 NZ_CP096570:1142706-1142900 [Xanthomonas translucens pv. undulosa]
ATGCCCCCGACAATCCGCGACGTGCTGCAACAACTCAGGGACGCAGGCTGGCAGCAAGTCGGCCAGACCGGCAGCTACCG
CCAGTTCAAGCATCCTGTCTACCCAGGCCGCGTGACAGTCACCGGCAAGCCGAGCGATGATGTGGCTCCCGGCACCCTGA
ACAGCATCCTGAAGCAAGCCGGCCTGAAGAGGTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8705.75 Da        Isoelectric Point: 4.5816

>AT197676 WP_014847289.1 NZ_CP072385:c969261-969016 [Arachnia propionica]
VSLNIKDEHIHDLVRRAATRTGLSQTRVVERAVVELLASLEAEAAASGLDQLLDRVHAELTASGGALDFDALYDPETGLP
R

Download         Length: 246 bp

>AT197676 NZ_CP096570:1142906-1143118 [Xanthomonas translucens pv. undulosa]
ATGCGCTACGCCGTCGTTATCGAGCAAGCGGGGAACAACTACTCTGCGTACGTGCCGGATCTGCCGGGGTGTGTGGCGAC
GGGTGAGACCACTGCCGAGGTCGAGGGATTGATCCGTGAAGCGATCGAGCTGCATCTGGCTGGGATGCGTGAAGATGGCG
AGGTGATTCCGCTGCCGTCGAGTCAGGTTGAGTATGTGGATGTGGCGGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P8ZRW0

Antitoxin

Source ID Structure
AlphaFold DB A0A4P8ZS27

References