Detailed information of TA system TA197676

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 968618..969261
• Replicon: chromosome
• Accession: NZ_CP072385
• Organism: Arachnia propionica strain F0714

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A4P8ZRW0
• Locus tag: J5A53_RS04365
• Protein ID: WP_014847290.1
• Coordinates: 968618..969019 (-)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A4P8ZS27
• Locus tag: J5A53_RS04370
• Protein ID: WP_014847289.1
• Coordinates: 969016..969261 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J5A53_RS04320 (J5A53_04320)	963632..963802	+	171	WP_014847298.1	50S ribosomal protein L33	-
J5A53_RS04325 (J5A53_04325)	963873..964301	+	429	WP_014847297.1	MaoC family dehydratase N-terminal domain-containing protein	-
J5A53_RS04330 (J5A53_04330)	964294..964707	+	414	WP_014847296.1	MaoC/PaaZ C-terminal domain-containing protein	-
J5A53_RS04335 (J5A53_04335)	964700..965722	+	1023	WP_014847295.1	UDP-N-acetylmuramate dehydrogenase	-
J5A53_RS15595	966267..966443	+	177	Protein_851	preprotein translocase subunit SecE	-
J5A53_RS04350 (J5A53_04350)	966440..967225	+	786	WP_014847293.1	transcription termination/antitermination protein NusG	-
J5A53_RS04355 (J5A53_04355)	967322..967750	+	429	WP_014847292.1	50S ribosomal protein L11	-
J5A53_RS04360 (J5A53_04360)	967834..968532	+	699	WP_014847291.1	50S ribosomal protein L1	-
J5A53_RS04365 (J5A53_04365)	968618..969019	-	402	WP_014847290.1	type II toxin-antitoxin system VapC family toxin	Toxin
J5A53_RS04370 (J5A53_04370)	969016..969261	-	246	WP_014847289.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
J5A53_RS04375 (J5A53_04375)	969456..969704	-	249	WP_041697718.1	type B 50S ribosomal protein L31	-
J5A53_RS04380 (J5A53_04380)	969789..970025	+	237	WP_014847287.1	50S ribosomal protein L28	-
J5A53_RS04385 (J5A53_04385)	970027..970194	+	168	WP_014847286.1	50S ribosomal protein L33	-
J5A53_RS04390 (J5A53_04390)	970566..971819	-	1254	WP_041696623.1	ATP-binding protein	-
J5A53_RS04395 (J5A53_04395)	971967..972350	-	384	WP_014847284.1	VOC family protein	-
J5A53_RS04400 (J5A53_04400)	972449..973417	+	969	WP_014847283.1	WYL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-124)

Antitoxin

• Antitoxin VapB-like (2-76)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 13978.00 Da
• Isoelectric Point: 5.6079

>T197676 WP_014847290.1 NZ_CP072385:c969019-968618 [Arachnia propionica]
MIVDPSAIAAILLKEPESSGFRELLGRRGGQLSAPGYLELSIVLTARGVTDPVATLDAILLGLGVEVVPFTPSQARLAQE
AHLRFGRGSGHPARLNFGDCISYALAKDTGEPLLFKGNDFVHTDLNPASGISP

Nucleotide

• Length: 402 bp

>T197676 NZ_CP096570:1142706-1142900 [Xanthomonas translucens pv. undulosa]
ATGCCCCCGACAATCCGCGACGTGCTGCAACAACTCAGGGACGCAGGCTGGCAGCAAGTCGGCCAGACCGGCAGCTACCG
CCAGTTCAAGCATCCTGTCTACCCAGGCCGCGTGACAGTCACCGGCAAGCCGAGCGATGATGTGGCTCCCGGCACCCTGA
ACAGCATCCTGAAGCAAGCCGGCCTGAAGAGGTAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8705.75 Da
• Isoelectric Point: 4.5816

>AT197676 WP_014847289.1 NZ_CP072385:c969261-969016 [Arachnia propionica]
VSLNIKDEHIHDLVRRAATRTGLSQTRVVERAVVELLASLEAEAAASGLDQLLDRVHAELTASGGALDFDALYDPETGLP
R

Nucleotide

• Length: 246 bp

>AT197676 NZ_CP096570:1142906-1143118 [Xanthomonas translucens pv. undulosa]
ATGCGCTACGCCGTCGTTATCGAGCAAGCGGGGAACAACTACTCTGCGTACGTGCCGGATCTGCCGGGGTGTGTGGCGAC
GGGTGAGACCACTGCCGAGGTCGAGGGATTGATCCGTGAAGCGATCGAGCTGCATCTGGCTGGGATGCGTGAAGATGGCG
AGGTGATTCCGCTGCCGTCGAGTCAGGTTGAGTATGTGGATGTGGCGGCTTGA

Structures

Toxin

• AlphaFold DB: A0A4P8ZRW0

Antitoxin

• AlphaFold DB: A0A4P8ZS27