Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 661789..662354 Replicon chromosome
Accession NZ_CP072385
Organism Arachnia propionica strain F0714

Toxin (Protein)


Gene name vapC Uniprot ID A0A3N4CZH7
Locus tag J5A53_RS02915 Protein ID WP_014847549.1
Coordinates 661992..662354 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A3N4D1U3
Locus tag J5A53_RS02910 Protein ID WP_014847550.1
Coordinates 661789..661995 (+) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J5A53_RS02895 (J5A53_02895) 658913..659953 + 1041 WP_014847553.1 glycoside hydrolase family 76 protein -
J5A53_RS02900 (J5A53_02900) 659963..660979 - 1017 WP_123824095.1 alpha/beta hydrolase -
J5A53_RS02905 (J5A53_02905) 661045..661611 + 567 WP_014847551.1 TetR family transcriptional regulator C-terminal domain-containing protein -
J5A53_RS02910 (J5A53_02910) 661789..661995 + 207 WP_014847550.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
J5A53_RS02915 (J5A53_02915) 661992..662354 + 363 WP_014847549.1 type II toxin-antitoxin system VapC family toxin Toxin
J5A53_RS02920 (J5A53_02920) 662755..663474 - 720 WP_071162217.1 hypothetical protein -
J5A53_RS02925 (J5A53_02925) 663868..665244 + 1377 WP_041696701.1 UTP--glucose-1-phosphate uridylyltransferase -
J5A53_RS02930 (J5A53_02930) 665247..665591 + 345 WP_014847545.1 hypothetical protein -
J5A53_RS15565 665639..666256 - 618 WP_234028367.1 large conductance mechanosensitive channel protein MscL -
J5A53_RS02940 (J5A53_02940) 666291..666905 - 615 WP_014847542.1 SAF domain-containing protein -
J5A53_RS02945 (J5A53_02945) 666974..667243 - 270 WP_014847541.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13682.99 Da        Isoelectric Point: 7.9144

>T197675 WP_014847549.1 NZ_CP072385:661992-662354 [Arachnia propionica]
VILVDTSVWIDHFRRSDLRLVRLLRGDEAGCHAMVIGELSLSSMPARTVRMSYLSNLYRFPSLHDDELLHLVETRRLWGR
GLSLVDVNLIGSVLVVPGACLWTRDKRLRAVAKELEIAFE

Download         Length: 363 bp

>T197675 NZ_CP096570:c917748-917596 [Xanthomonas translucens pv. undulosa]
ATGAAGCGACTGTTCACCTTGACGATGCTGACCCTGTTTTGTGCAGGCATGCTGACCGGCTGCAACACCATGGCCGGCGC
CGGTAAGGACATGCAGAAGGCCGGCGATAAGGTGGAAACCAAGGCCGACGACTGTAAAGACGGCAAGTGCTGA

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7449.47 Da        Isoelectric Point: 5.0807

>AT197675 WP_014847550.1 NZ_CP072385:661789-661995 [Arachnia propionica]
MRTTVTLDDDLVARAQELTGVKERSVLLREGLETLIRVESARRLAALGGTEPEAQISSRTRDLGDLAK

Download         Length: 207 bp

>AT197675 NZ_CP096570:c917497-917363 [Xanthomonas translucens pv. undulosa]
ATGAAGCGTACTTTCGCGTGGATGCTGCTGGCGATGTTCTCGGTGGGCCTGCTGTCGGGCTGCAACACGGTTGCCGGTGC
CGGCAAGGACGTGAAGAGCGCCGGCGAGAAGGTCGAAGACGCCGCCAAGAACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3N4CZH7

Antitoxin

Source ID Structure
AlphaFold DB A0A3N4D1U3

References