Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2976486..2977114 Replicon chromosome
Accession NZ_CP072384
Organism Arachnia rubra strain DSMZ 100122

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag J5A65_RS13445 Protein ID WP_223927621.1
Coordinates 2976716..2977114 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag J5A65_RS13440 Protein ID WP_212323090.1
Coordinates 2976486..2976719 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J5A65_RS13415 (J5A65_13415) 2972155..2973087 - 933 WP_212323075.1 ABC transporter ATP-binding protein -
J5A65_RS13420 (J5A65_13420) 2973328..2974326 - 999 WP_212323078.1 serine hydrolase domain-containing protein -
J5A65_RS13425 (J5A65_13425) 2974468..2974908 - 441 WP_212323081.1 hypothetical protein -
J5A65_RS13430 (J5A65_13430) 2974990..2976006 - 1017 WP_212323084.1 hypothetical protein -
J5A65_RS13435 (J5A65_13435) 2976003..2976353 - 351 WP_212323087.1 GntR family transcriptional regulator -
J5A65_RS13440 (J5A65_13440) 2976486..2976719 + 234 WP_212323090.1 hypothetical protein Antitoxin
J5A65_RS13445 (J5A65_13445) 2976716..2977114 + 399 WP_223927621.1 PIN domain-containing protein Toxin
J5A65_RS13450 (J5A65_13450) 2977177..2977947 + 771 WP_212323093.1 peroxide stress protein YaaA -
J5A65_RS13455 (J5A65_13455) 2978336..2978881 + 546 WP_212323096.1 NAD(P)H-dependent oxidoreductase -
J5A65_RS13465 (J5A65_13465) 2980501..2980677 - 177 WP_212323102.1 plantaricin C family lantibiotic -
J5A65_RS13470 (J5A65_13470) 2981071..2981979 + 909 WP_212323105.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14374.51 Da        Isoelectric Point: 5.1094

>T197671 WP_223927621.1 NZ_CP072384:2976716-2977114 [Arachnia rubra]
MIRYLLDANVLIALTAAEHEHHEAAGEWLAETTQFATCPTTESALLRFLLGLGEPATMALERIRLIRALPAAEFWPSDLS
YADIDATGLIGHRQATDLYLVSLAAAHGGLLATFDKALHASRPDLTFLIPRP

Download         Length: 399 bp

>T197671 NZ_CP096540:c2249836-2249474 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAACAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAGCAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTAAATGCAGTAGCTCATCAGAAAAATTAG

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8404.51 Da        Isoelectric Point: 4.5184

>AT197671 WP_212323090.1 NZ_CP072384:2976486-2976719 [Arachnia rubra]
MRTTVDLPPAVRERAQEIAQLQGRSLSAVVAELATRGLAQLDDHPAIIETDPRTGFPVLRIGRSITNEQVADLIEES

Download         Length: 234 bp

>AT197671 NZ_CP096540:c2250003-2249833 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References