Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapB(antitoxin)
Location 2728585..2729150 Replicon chromosome
Accession NZ_CP072384
Organism Arachnia rubra strain DSMZ 100122

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag J5A65_RS12400 Protein ID WP_212322423.1
Coordinates 2728585..2728947 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag J5A65_RS12405 Protein ID WP_212322425.1
Coordinates 2728944..2729150 (-) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J5A65_RS12385 (J5A65_12385) 2725454..2726716 + 1263 WP_212322419.1 sugar ABC transporter substrate-binding protein -
J5A65_RS12390 (J5A65_12390) 2726827..2727660 + 834 WP_212327801.1 sugar ABC transporter permease -
J5A65_RS12395 (J5A65_12395) 2727653..2728498 + 846 WP_212322421.1 carbohydrate ABC transporter permease -
J5A65_RS12400 (J5A65_12400) 2728585..2728947 - 363 WP_212322423.1 VapC toxin family PIN domain ribonuclease Toxin
J5A65_RS12405 (J5A65_12405) 2728944..2729150 - 207 WP_212322425.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
J5A65_RS12410 (J5A65_12410) 2729373..2730419 - 1047 WP_212322428.1 glycoside hydrolase family 76 protein -
J5A65_RS12415 (J5A65_12415) 2730515..2730856 - 342 WP_212322431.1 Imm51 family immunity protein -
J5A65_RS12420 (J5A65_12420) 2731053..2732753 + 1701 WP_212327804.1 NAD-dependent malic enzyme -
J5A65_RS12425 (J5A65_12425) 2732923..2733582 + 660 WP_212322443.1 hypothetical protein -
J5A65_RS12430 (J5A65_12430) 2733746..2734141 - 396 WP_212322447.1 SdpI family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13722.00 Da        Isoelectric Point: 6.8728

>T197669 WP_212322423.1 NZ_CP072384:c2728947-2728585 [Arachnia rubra]
VILVDTSVWIDHFRRSDLRLVRLLRGDEAGCHAMVIGELALSSMPARSVRMSYLENLHRFPSLQDDEMLHLVESRRLWGR
GLSLVDVNLLGAVLVVPGARLWTRDKRLKSMAEELEIAFE

Download         Length: 363 bp

>T197669 NZ_CP096540:c1663460-1663209 [Staphylococcus aureus]
ATGAATAATCGCGAAAAAATCGAACAGTCCGTTATTAGTGCTAGTGCGTATAACGGTAATGACACAGAGGGGTTGCTAAA
AGAGATTGAGGACGTGTATAAGAAAGCACAAGCGTTTGATGAAATACTTGAGGGAATGACAAATGCTATTCAACATTCAG
TTAAAGAAGGTATTGAACTTGATGAAGCAGTAGGGATTATGACGGGGCAAGTGGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7390.36 Da        Isoelectric Point: 5.0807

>AT197669 WP_212322425.1 NZ_CP072384:c2729150-2728944 [Arachnia rubra]
MRTTVTLDDDLVSRAQELTGVKERSVLLREGLETLIRVESARRLAALGGAEPEAQASARNRDLGDLAK

Download         Length: 207 bp

>AT197669 NZ_CP096540:c1663219-1663046 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References