Detailed information of TA system TA197668

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 392488..393167
• Replicon: chromosome
• Accession: NZ_CP072384
• Organism: Arachnia rubra strain DSMZ 100122

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: J5A65_RS01695
• Protein ID: WP_212324454.1
• Coordinates: 392736..393167 (+)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: J5A65_RS01690
• Protein ID: WP_212324452.1
• Coordinates: 392488..392736 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J5A65_RS01675 (J5A65_01675)	388037..390127	-	2091	WP_212324446.1	hypothetical protein	-
J5A65_RS01680 (J5A65_01680)	390214..390603	-	390	WP_212324448.1	nuclear transport factor 2 family protein	-
J5A65_RS01685 (J5A65_01685)	390780..391946	-	1167	WP_212324450.1	hypothetical protein	-
J5A65_RS01690 (J5A65_01690)	392488..392736	+	249	WP_212324452.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
J5A65_RS01695 (J5A65_01695)	392736..393167	+	432	WP_212324454.1	type II toxin-antitoxin system VapC family toxin	Toxin
J5A65_RS01700 (J5A65_01700)	393277..394557	-	1281	WP_212324456.1	alpha/beta hydrolase	-
J5A65_RS01705 (J5A65_01705)	394785..395972	+	1188	WP_212324458.1	glycosyltransferase	-
J5A65_RS01710 (J5A65_01710)	395969..397168	+	1200	WP_212324460.1	glycosyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-127)

Antitoxin

• SpoVT-AbrB domain (8-53)

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 15708.97 Da
• Isoelectric Point: 4.9670

>T197668 WP_212324454.1 NZ_CP072384:392736-393167 [Arachnia rubra]
MRYLLDTNIVGQLMRAHPVALERLARHGTDRVFISAITEAEICFGLAKRPAAARLHRAVEVLREQVEVLDFTARTALVYG
SLRADLESSGMPMSPLDTLIAATALEHRQDDADIVLVTSDHAFSRIPGLVVEDWTVEACGEGQ

Nucleotide

• Length: 432 bp

>T197668 NZ_CP096540:c959666-959478 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9075.94 Da
• Isoelectric Point: 4.1705

>AT197668 WP_212324452.1 NZ_CP072384:392488-392736 [Arachnia rubra]
VSQVTTVFKNGGSQAVRIPAAYRFDTDRVYIRRDDNGDVVLSTRPGAWDAFIEAVTGLDVPDDFLAPETRQAEERNLFDG
EG

Nucleotide

• Length: 249 bp

>AT197668 NZ_CP096540:c959954-959694 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA