197667

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 269528..270051 Replicon chromosome
Accession NZ_CP072384
Organism Arachnia rubra strain DSMZ 100122

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag J5A65_RS01100 Protein ID WP_212324214.1
Coordinates 269794..270051 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag J5A65_RS01095 Protein ID WP_212324212.1
Coordinates 269528..269797 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J5A65_RS01065 (J5A65_01065) 264600..265562 + 963 WP_212324196.1 bile acid:sodium symporter family protein -
J5A65_RS01070 (J5A65_01070) 265613..266221 - 609 WP_223927699.1 DJ-1/PfpI family protein -
J5A65_RS01075 (J5A65_01075) 266406..267374 + 969 WP_212324204.1 hypothetical protein -
J5A65_RS01080 (J5A65_01080) 267352..268170 + 819 WP_212324206.1 hypothetical protein -
J5A65_RS01085 (J5A65_01085) 268167..268787 - 621 WP_212324208.1 ribonuclease D -
J5A65_RS01090 (J5A65_01090) 268951..269307 - 357 WP_212324210.1 hypothetical protein -
J5A65_RS01095 (J5A65_01095) 269528..269797 + 270 WP_212324212.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
J5A65_RS01100 (J5A65_01100) 269794..270051 + 258 WP_212324214.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J5A65_RS15040 270716..271018 - 303 WP_244980175.1 transposase -
J5A65_RS01110 (J5A65_01110) 271006..271827 - 822 WP_244980176.1 ISAs1 family transposase -
J5A65_RS01115 (J5A65_01115) 271978..272745 + 768 WP_223927909.1 IS3 family transposase -
J5A65_RS01125 (J5A65_01125) 272958..273713 - 756 WP_212323263.1 transposase family protein -
J5A65_RS01130 (J5A65_01130) 273847..274717 + 871 Protein_223 IS1634 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 256106..278965 22859
- flank IS/Tn - - 274934..275164 230


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(6-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9777.25 Da        Isoelectric Point: 10.6715

>T197667 WP_212324214.1 NZ_CP072384:269794-270051 [Arachnia rubra]
MTTPREIAWRPAARRALGRLPEKVATAAIEFVYGPLADNPYRVGKPLRFELEGLHSARRGNYRVIYRSAERIEIIAVEHR
ADAYR

Download         Length: 258 bp

>T197667 NZ_CP096540:914756-915007 [Staphylococcus aureus]
ATGAATAATCGCGAAAAAATCGAACAGTCCGTTATTAGTGCTAGTGCGTATAACGGTAATGACACAGAGGGGTTGCTAAA
AGAGATTGAGGACGTGTATAAGAAAGCACAAGCGTTTGATGAAATACTTGAGGGAATGACAAATGCTATTCAACATTCAG
TTAAAGAAGGTATTGAACTTGATGAAGCAGTAGGGATTATGACGGGGCAAGTGGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9750.24 Da        Isoelectric Point: 4.6768

>AT197667 WP_212324212.1 NZ_CP072384:269528-269797 [Arachnia rubra]
MSMEQAMPLREVKNRLSEVVDRVAGQHDRVVITRHGRPAAVVLSPDDLASLEETLDVMGCPRLLADIRESLAAEGEVMSK
EEILAALGR

Download         Length: 270 bp

>AT197667 NZ_CP096540:914997-915170 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References