Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA-HipB |
| Location | 1309248..1310806 | Replicon | chromosome |
| Accession | NZ_CP072381 | ||
| Organism | Aggregatibacter sp. oral taxon 513 strain W11186 | ||
Toxin (Protein)
| Gene name | hipA | Uniprot ID | - |
| Locus tag | J5A60_RS06250 | Protein ID | WP_212509806.1 |
| Coordinates | 1309526..1310806 (+) | Length | 427 a.a. |
Antitoxin (Protein)
| Gene name | hipB | Uniprot ID | - |
| Locus tag | J5A60_RS06245 | Protein ID | WP_109063854.1 |
| Coordinates | 1309248..1309526 (+) | Length | 93 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J5A60_RS06225 (J5A60_06225) | 1304420..1304902 | - | 483 | WP_212509802.1 | Dps family protein | - |
| J5A60_RS06230 (J5A60_06230) | 1305098..1306258 | + | 1161 | WP_212509803.1 | EmrA/EmrK family multidrug efflux transporter periplasmic adaptor subunit | - |
| J5A60_RS06235 (J5A60_06235) | 1306271..1307785 | + | 1515 | WP_212509804.1 | DHA2 family efflux MFS transporter permease subunit | - |
| J5A60_RS06240 (J5A60_06240) | 1308038..1309093 | + | 1056 | WP_212509805.1 | ABC transporter substrate-binding protein | - |
| J5A60_RS06245 (J5A60_06245) | 1309248..1309526 | + | 279 | WP_109063854.1 | helix-turn-helix domain-containing protein | Antitoxin |
| J5A60_RS06250 (J5A60_06250) | 1309526..1310806 | + | 1281 | WP_212509806.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
| J5A60_RS06255 (J5A60_06255) | 1310889..1313753 | - | 2865 | WP_212509807.1 | valine--tRNA ligase | - |
| J5A60_RS06260 (J5A60_06260) | 1313835..1314275 | - | 441 | WP_212509808.1 | hypothetical protein | - |
| J5A60_RS06265 (J5A60_06265) | 1314266..1314571 | - | 306 | WP_212509809.1 | N(4)-acetylcytidine aminohydrolase | - |
| J5A60_RS06270 (J5A60_06270) | 1314645..1315091 | - | 447 | WP_212509810.1 | DNA polymerase III subunit chi | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 427 a.a. Molecular weight: 49084.39 Da Isoelectric Point: 7.9979
>T197666 WP_212509806.1 NZ_CP072381:1309526-1310806 [Aggregatibacter sp. oral taxon 513]
MSNSILNVAMNGLLVGEWRKLTSGATEFQYAEKWLESVRSRPISLSLPLSHKIYRGDSVYNFFDNLLPDNEQIRSRIQQR
FQTSTKSPFDLLSAIGQDCIGAIQLYQGQSRSVRQIYAEPLNDKEVENVLKNYRTFPLGMEESEDFRISLAGAQEKTALL
YYQNQWQRPLHSTATSHIFKLPIGMVAQGQIDLSSSCENEWLCLNLMKAFGLPVPRSQIQHFGEMKVLIVERFDRRWSEN
RSWLIRLPQEDMCQALNIAPARKYENDGGPSILQIMSLLNGSSSAQADRKQFFKAQIIFWLLCAIDGHGKNFSLFLEQEN
RYRLTPFYDVMSAYPLIKHNGLQKQKVKMAMAWHGENKHYLWDKIQLRHIFNTAKLAGLAKETVEDILHEICALYPRVSE
INTHGLPDEIVDPIFMGLEMQMKKIS
MSNSILNVAMNGLLVGEWRKLTSGATEFQYAEKWLESVRSRPISLSLPLSHKIYRGDSVYNFFDNLLPDNEQIRSRIQQR
FQTSTKSPFDLLSAIGQDCIGAIQLYQGQSRSVRQIYAEPLNDKEVENVLKNYRTFPLGMEESEDFRISLAGAQEKTALL
YYQNQWQRPLHSTATSHIFKLPIGMVAQGQIDLSSSCENEWLCLNLMKAFGLPVPRSQIQHFGEMKVLIVERFDRRWSEN
RSWLIRLPQEDMCQALNIAPARKYENDGGPSILQIMSLLNGSSSAQADRKQFFKAQIIFWLLCAIDGHGKNFSLFLEQEN
RYRLTPFYDVMSAYPLIKHNGLQKQKVKMAMAWHGENKHYLWDKIQLRHIFNTAKLAGLAKETVEDILHEICALYPRVSE
INTHGLPDEIVDPIFMGLEMQMKKIS
Download Length: 1281 bp
>T197666 NZ_CP096540:c357883-357422 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTGGA
TGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGCTTATCAGATAGAGAAAAGGCAGGAATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGG
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAAGCTTACAATTATGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTGCAATTGAGTGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGGACTC
ACTACGGCGAATACTCAATTACATTTGAGCCATTGAGAGTTTTTAAATATAAAGAAATATAA
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTGGA
TGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGCTTATCAGATAGAGAAAAGGCAGGAATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGG
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAAGCTTACAATTATGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTGCAATTGAGTGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGGACTC
ACTACGGCGAATACTCAATTACATTTGAGCCATTGAGAGTTTTTAAATATAAAGAAATATAA
Antitoxin
Download Length: 93 a.a. Molecular weight: 10395.79 Da Isoelectric Point: 5.1473
>AT197666 WP_109063854.1 NZ_CP072381:1309248-1309526 [Aggregatibacter sp. oral taxon 513]
MVITTAKMLSHVIREFRYQGDLSQTDVAKLAGTTQARISAFENEPERTKLETLFKILAGLELELIVQPRKKSSDTAHSIK
EPTATYDDDEAW
MVITTAKMLSHVIREFRYQGDLSQTDVAKLAGTTQARISAFENEPERTKLETLFKILAGLELELIVQPRKKSSDTAHSIK
EPTATYDDDEAW
Download Length: 279 bp
>AT197666 NZ_CP096540:c358210-357896 [Staphylococcus aureus]
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTGGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAGCGTTATGAAAGCGGAAATATCAAAAATTTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCATATTTAATGGGGTGGGTTGAAGAAAACGATGATGAAGTACAACATCGTGCAGCTCACCTT
GAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGCAAACGTAAGTAA
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTGGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAGCGTTATGAAAGCGGAAATATCAAAAATTTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCATATTTAATGGGGTGGGTTGAAGAAAACGATGATGAAGTACAACATCGTGCAGCTCACCTT
GAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGCAAACGTAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|