Detailed information of TA system TA197665

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 2157315..2157866
• Replicon: chromosome
• Accession: NZ_CP072380
• Organism: Atopobium sp. oral taxon 416 strain W9116

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: J4859_RS11290
• Protein ID: WP_212329898.1
• Coordinates: 2157315..2157593 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: J4859_RS11295
• Protein ID: WP_212329899.1
• Coordinates: 2157594..2157866 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J4859_RS11270 (J4859_11265)	2153363..2154199	+	837	WP_212329890.1	alpha/beta hydrolase	-
J4859_RS11275 (J4859_11270)	2154770..2155174	+	405	WP_212329892.1	hypothetical protein	-
J4859_RS17065	2156070..2156192	+	123	WP_256436732.1	hypothetical protein	-
J4859_RS11280 (J4859_11275)	2156337..2156642	+	306	WP_212329894.1	hypothetical protein	-
J4859_RS11285 (J4859_11280)	2157022..2157282	+	261	WP_249113621.1	HNH endonuclease signature motif containing protein	-
J4859_RS11290 (J4859_11285)	2157315..2157593	-	279	WP_212329898.1	type II toxin-antitoxin system YafQ family toxin	Toxin
J4859_RS11295 (J4859_11290)	2157594..2157866	-	273	WP_212329899.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
J4859_RS11300 (J4859_11295)	2158757..2158936	-	180	WP_212329900.1	hypothetical protein	-
J4859_RS11305 (J4859_11300)	2159168..2159347	-	180	WP_256436880.1	transposase	-
J4859_RS11310 (J4859_11305)	2159415..2159687	-	273	WP_212329902.1	hypothetical protein	-
J4859_RS11315 (J4859_11310)	2159736..2160014	-	279	WP_212329903.1	transposase	-
J4859_RS17070 (J4859_11315)	2160503..2160706	-	204	WP_212335448.1	hypothetical protein	-
J4859_RS17075	2160608..2160871	+	264	WP_256436881.1	hypothetical protein	-
J4859_RS11325 (J4859_11320)	2160756..2161526	+	771	Protein_2229	ThiF family adenylyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (1-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-66)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10679.50 Da
• Isoelectric Point: 7.8794

>T197665 WP_212329898.1 NZ_CP072380:c2157593-2157315 [Atopobium sp. oral taxon 416]
MLTVKFTTAYKKSYKLMKKRGENLSLLEEVVDALRQGKVLDKRFCDHELKGNLKGFRECHIQPDWLLIYLIENDILTLTL
VDTGSHSDLLNL

Nucleotide

• Length: 279 bp

>T197665 NZ_CP096539:c2142719-2142510 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATTGATGGTCAAGTAACGGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATTTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10049.52 Da
• Isoelectric Point: 5.0649

>AT197665 WP_212329899.1 NZ_CP072380:c2157866-2157594 [Atopobium sp. oral taxon 416]
MSTVPTQIRIDANVKKQANELFSELGMDMSGAVNIFLRQCILRGGLPFTVEVPQYSQKVLDAMSEARRISRDPGVSGYTN
MDDLRKALEE

Nucleotide

• Length: 273 bp

>AT197665 NZ_CP096539:c2143024-2142731 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGAGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA