Detailed information of TA system TA197661

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 1536516..1537065
• Replicon: chromosome
• Accession: NZ_CP072377
• Organism: Leptotrichia sp. oral taxon 218 strain F0707

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: J5A73_RS07200
• Protein ID: WP_211614419.1
• Coordinates: 1536781..1537065 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: J5A73_RS07195
• Protein ID: WP_094079111.1
• Coordinates: 1536516..1536794 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J5A73_RS07170 (J5A73_07170)	1532270..1532833	-	564	WP_211614413.1	nucleotide exchange factor GrpE	-
J5A73_RS07175 (J5A73_07175)	1532851..1533855	-	1005	WP_211614415.1	heat-inducible transcriptional repressor HrcA	-
J5A73_RS07180 (J5A73_07180)	1534181..1534864	+	684	WP_211614417.1	DUF3800 domain-containing protein	-
J5A73_RS07185 (J5A73_07185)	1535716..1535901	+	186	WP_021743949.1	hypothetical protein	-
J5A73_RS07190 (J5A73_07190)	1535879..1536454	+	576	WP_021743948.1	hypothetical protein	-
J5A73_RS07195 (J5A73_07195)	1536516..1536794	+	279	WP_094079111.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
J5A73_RS07200 (J5A73_07200)	1536781..1537065	+	285	WP_211614419.1	type II toxin-antitoxin system YafQ family toxin	Toxin
J5A73_RS07205 (J5A73_07205)	1537342..1537668	-	327	WP_211614421.1	helix-turn-helix transcriptional regulator	-
J5A73_RS07210 (J5A73_07210)	1537876..1538475	+	600	WP_211614423.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	-
J5A73_RS07215 (J5A73_07215)	1538472..1539305	+	834	WP_211614425.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	-
J5A73_RS07220 (J5A73_07220)	1539466..1539663	+	198	WP_211614427.1	XRE family transcriptional regulator	-
J5A73_RS07225 (J5A73_07225)	1539767..1540126	+	360	WP_211614429.1	hypothetical protein	-
J5A73_RS07230 (J5A73_07230)	1540283..1540693	+	411	WP_211614431.1	hypothetical protein	-
J5A73_RS07235 (J5A73_07235)	1540733..1541623	+	891	WP_211614433.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-87)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (2-86)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11261.47 Da
• Isoelectric Point: 10.4168

>T197661 WP_211614419.1 NZ_CP072377:1536781-1537065 [Leptotrichia sp. oral taxon 218]
MKMNKYNLKYTNRFSKDLKLIKKRGYNLKLLEKVVEILINREKLSVKNKDYALKNKYLGYRECCITSDWLLVYKIKGEEL
IFLTTKTKTPSSLF

Nucleotide

• Length: 285 bp

>T197661 NZ_CP096539:c875191-875003 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10632.19 Da
• Isoelectric Point: 5.2273

>AT197661 WP_094079111.1 NZ_CP072377:1536516-1536794 [Leptotrichia sp. oral taxon 218]
MPTVSTSIKIDAKTKKEAQELFKDMGMSLTAAINIFLKQAVREQRIPFYVGEPKYKEEVYQAMKDVEQGKNLSKSYHSAR
EMIEDILKDEDE

Nucleotide

• Length: 279 bp

>AT197661 NZ_CP096539:c875479-875219 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA