Detailed information of TA system TA197659

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 1070988..1071588
• Replicon: chromosome
• Accession: NZ_CP072377
• Organism: Leptotrichia sp. oral taxon 218 strain F0707

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: J5A73_RS04990
• Protein ID: WP_211617174.1
• Coordinates: 1070988..1071308 (-)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: J5A73_RS04995
• Protein ID: WP_211617176.1
• Coordinates: 1071298..1071588 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J5A73_RS04975 (J5A73_04975)	1067160..1069178	+	2019	WP_211617168.1	NAD-dependent DNA ligase LigA	-
J5A73_RS04980 (J5A73_04980)	1069399..1069884	-	486	WP_211617170.1	hypothetical protein	-
J5A73_RS04985 (J5A73_04985)	1070008..1071015	-	1008	WP_211617172.1	class 1b ribonucleoside-diphosphate reductase subunit beta	-
J5A73_RS04990 (J5A73_04990)	1070988..1071308	-	321	WP_211617174.1	type II toxin-antitoxin system YafQ family toxin	Toxin
J5A73_RS04995 (J5A73_04995)	1071298..1071588	-	291	WP_211617176.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
J5A73_RS05000 (J5A73_05000)	1071664..1072521	-	858	WP_211617178.1	Fic family protein	-
J5A73_RS05005 (J5A73_05005)	1072544..1075648	-	3105	WP_211617180.1	LAGLIDADG family homing endonuclease	-
J5A73_RS05010 (J5A73_05010)	1075739..1076110	-	372	WP_211617182.1	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	-
J5A73_RS05015 (J5A73_05015)	1076216..1076455	-	240	WP_211617183.1	glutaredoxin domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1067160..1088604	21444

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (12-86)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (6-75)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12902.35 Da
• Isoelectric Point: 10.5211

>T197659 WP_211617174.1 NZ_CP072377:c1071308-1070988 [Leptotrichia sp. oral taxon 218]
MRDKKEEYKYSIILTGKFKKHLKNLKKQKKDLKLLESIISILAKGEKLPPKNKDHKLVNNYDGARECHITPDWLLIYEIV
EDKLILIKQFYQERKTKKWKRKYTKQ

Nucleotide

• Length: 321 bp

>T197659 NZ_CP096535:c2161461-2161099 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAACAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAGCAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTAAATGCAGTAGCTCATCAGAAAAATTAG

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10924.42 Da
• Isoelectric Point: 4.7049

>AT197659 WP_211617176.1 NZ_CP072377:c1071588-1071298 [Leptotrichia sp. oral taxon 218]
MATVNISIKIDEETKKEAQKLFKDLGLSLSTTINIFLKQAIREKGIPFYISSLPENSELVQAFEEAKQIKKNPSNYKSYS
SPEEMFKDVLGEDYEG

Nucleotide

• Length: 291 bp

>AT197659 NZ_CP096535:c2161628-2161458 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA