Detailed information of TA system TA197658

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 1683697..1685333
• Replicon: chromosome
• Accession: NZ_CP072363
• Organism: Prevotella jejuni strain F0697

Toxin (Protein)

• Gene name: HipA3
• Uniprot ID: -
• Locus tag: J4857_RS06720
• Protein ID: WP_211818149.1
• Coordinates: 1683999..1685333 (+)
• Length: 445 a.a.

Antitoxin (Protein)

• Gene name: HipB3
• Uniprot ID: -
• Locus tag: J4857_RS06715
• Protein ID: WP_107626034.1
• Coordinates: 1683697..1684002 (+)
• Length: 102 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J4857_RS06700 (J4857_06700)	1679763..1680896	+	1134	WP_211818146.1	M23 family metallopeptidase	-
J4857_RS06705 (J4857_06705)	1680900..1681070	+	171	WP_211818147.1	hypothetical protein	-
J4857_RS06710 (J4857_06710)	1681079..1683502	+	2424	WP_211818148.1	hypothetical protein	-
J4857_RS06715 (J4857_06715)	1683697..1684002	+	306	WP_107626034.1	helix-turn-helix domain-containing protein	Antitoxin
J4857_RS06720 (J4857_06720)	1683999..1685333	+	1335	WP_211818149.1	type II toxin-antitoxin system HipA family toxin	Toxin
J4857_RS06725 (J4857_06725)	1685747..1686091	+	345	WP_211818150.1	transposase family protein	-
J4857_RS06730 (J4857_06730)	1686207..1687076	+	870	WP_211818151.1	transposase	-
J4857_RS06735 (J4857_06735)	1687443..1687913	+	471	WP_211818152.1	hypothetical protein	-
J4857_RS06740 (J4857_06740)	1688223..1688675	+	453	Protein_1343	hypothetical protein	-
J4857_RS06745 (J4857_06745)	1689141..1689578	+	438	WP_211818153.1	hypothetical protein	-
J4857_RS06750 (J4857_06750)	1689804..1690025	+	222	WP_211818154.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (173-407)

Antitoxin

• Cro/C1-type helix-turn-helix domain (18-65)

Sequences

Toxin

Protein

• Length: 445 a.a.
• Molecular weight: 50681.36 Da
• Isoelectric Point: 6.8274

>T197658 WP_211818149.1 NZ_CP072363:1683999-1685333 [Prevotella jejuni]
MKDLVVTISLYGRTVGYASWDNNRGSASFEFEPKFINSGLNVSPLIMPLAKSKGRVYNFPENINNCFGGLPGMLSDSLPD
KYGSEKIDAYFASKGLLTSDVTPLDRLCYIGKRGMGALEFEPSNSYKDLEESSALDIQAIVDVAKEIFQSREMFKDLLNQ
KDKRIIDILKVGTSAGGAKPKAIIAYNDETNEVRSGQVKAPEGFGYWLLKFDGGEFLEHNQICENPKGIGQIEYAYYKMA
KAAGIDMNECRLLEEGDSHHFMTRRFDRTMTGEKIHMQTLAAIAHYNRDERHSYEQLFEVMRKLDLPYTDYREMFRRMVF
NVAARNHDDHTKNHSFLMDRNGKWSLAPAYDLCYSYNKNGKFTKYHQMFLNGKQDNFTYNDLKNVADNIGIKFSENIINE
VMDVTAEWKSFAKEAGVRREYSEEINDNILSLKSSPGISKGIRR

Nucleotide

• Length: 1335 bp

>T197658 NZ_CP096535:c1999604-1999452 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACTGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATTTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin

Protein

• Length: 102 a.a.
• Molecular weight: 11468.67 Da
• Isoelectric Point: 11.0185

>AT197658 WP_107626034.1 NZ_CP072363:1683697-1684002 [Prevotella jejuni]
MWKEKSNPSILKEIGKRIQRERLRQDITQACLAESSGVSLIVVQRIEKGMSISLQNLLGILRALNMLEGLEQLFPEPPIS
PILLKKLSGKTRKRASKNIYK

Nucleotide

• Length: 306 bp

>AT197658 NZ_CP096535:c2000228-1999629 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTACTAGATGAATTAAAGAAAAATGTAG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAACAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACTGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTTGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
CGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA