Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sezT-pezT/zeta-couple_hipB
Location 349550..350796 Replicon chromosome
Accession NZ_CP072329
Organism Streptococcus lactarius strain CCUG 66490

Toxin (Protein)


Gene name sezT Uniprot ID -
Locus tag J4854_RS01895 Protein ID WP_200773149.1
Coordinates 350026..350796 (+) Length 257 a.a.

Antitoxin (Protein)


Gene name pezT Uniprot ID -
Locus tag J4854_RS01890 Protein ID WP_200773150.1
Coordinates 349550..350026 (+) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4854_RS01870 (J4854_01870) 344824..345723 - 900 WP_200773204.1 tyrosine-type recombinase/integrase -
J4854_RS01880 (J4854_01880) 345816..348062 + 2247 WP_234700145.1 hypothetical protein -
J4854_RS01885 (J4854_01885) 348048..349310 - 1263 WP_200773430.1 hydoxy methyltransferase -
J4854_RS01890 (J4854_01890) 349550..350026 + 477 WP_200773150.1 type II toxin-antitoxin system antitoxin PezA Antitoxin
J4854_RS01895 (J4854_01895) 350026..350796 + 771 WP_200773149.1 type II toxin-antitoxin system toxin PezT Toxin
J4854_RS01900 (J4854_01900) 350849..352105 + 1257 WP_200773148.1 MFS transporter -
J4854_RS01905 (J4854_01905) 352341..352544 - 204 WP_200773147.1 CsbD family protein -
J4854_RS01910 (J4854_01910) 352861..353459 + 599 Protein_343 rhomboid family intramembrane serine protease -
J4854_RS01915 (J4854_01915) 353642..354670 + 1029 WP_200773146.1 NADP-dependent oxidoreductase -
J4854_RS01920 (J4854_01920) 354663..355298 + 636 WP_200773145.1 TetR/AcrR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(26-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 257 a.a.        Molecular weight: 29401.49 Da        Isoelectric Point: 9.1067

>T197657 WP_200773149.1 NZ_CP072329:350026-350796 [Streptococcus lactarius]
MKLEEFSQDDFERASRRLVRSLTRGKTTSSQPKAILLGGQSGAGKTTIHRIKQREFQGNIIIIDGDSYRSFHPNYLDLQE
KYGKDSVDYTKVFAGKMVEYLVDELSKLGYHLLIKGTLRTTEVPRKTAQLLTTRGYQVSLALIATKPELSYISTLIRYGE
LYAIDPRQARATPKEHHDGIVEHLVDNLRELENNKIFNQIQIFQRDQSCVYDSQVDQTSAAEVLHECLFGKLSKVEKEML
KLGQERLREFNTETKK

Download         Length: 771 bp

>T197657 NZ_CP096535:c872930-872742 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18023.47 Da        Isoelectric Point: 4.4367

>AT197657 WP_200773150.1 NZ_CP072329:349550-350026 [Streptococcus lactarius]
MIGENIKALRKTHNLTQPEFAKIVGISRNSLSRYENGTSSISTELIDRICQKFNVSYIDIVGEEKMLTPVEDYQLTLKIE
VIKERGANILAQLYRFQDEQGIAFDDTSNPWVLMSDDLSDLLNTKIYLVGTFDEVERFNGYLDGIERMLEQASHLVVA

Download         Length: 477 bp

>AT197657 NZ_CP096535:c873218-872958 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References