Detailed information of TA system TA197654

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2631995..2633559
• Replicon: chromosome
• Accession: NZ_CP072326
• Organism: Aeromonas caviae strain 21006

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A2S4TP05
• Locus tag: J6625_RS12385
• Protein ID: WP_005329232.1
• Coordinates: 2632249..2633559 (+)
• Length: 437 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: J6625_RS12380
• Protein ID: WP_005329233.1
• Coordinates: 2631995..2632249 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J6625_RS12355 (J6625_12290)	2627570..2628148	-	579	WP_021140685.1	hypothetical protein	-
J6625_RS12360 (J6625_12295)	2628480..2628932	-	453	WP_021140686.1	DUF2384 domain-containing protein	-
J6625_RS12365 (J6625_12300)	2629187..2630494	+	1308	WP_021140687.1	Fic family protein	-
J6625_RS12370 (J6625_12305)	2630573..2630824	+	252	WP_010674977.1	plasmid stabilization protein	-
J6625_RS12375 (J6625_12310)	2631245..2631493	-	249	WP_010674978.1	hypothetical protein	-
J6625_RS12380 (J6625_12315)	2631995..2632249	+	255	WP_005329233.1	helix-turn-helix domain-containing protein	Antitoxin
J6625_RS12385 (J6625_12320)	2632249..2633559	+	1311	WP_005329232.1	type II toxin-antitoxin system HipA family toxin	Toxin
J6625_RS12395 (J6625_12330)	2634519..2636693	+	2175	WP_010674980.1	catalase/peroxidase HPI	-
J6625_RS12400 (J6625_12335)	2637024..2638541	+	1518	WP_029314641.1	DUF1214 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-104)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 437 a.a.
• Molecular weight: 49096.31 Da
• Isoelectric Point: 7.1717

>T197654 WP_005329232.1 NZ_CP072326:2632249-2633559 [Aeromonas caviae]
MASLTVYMNGYRVGTFTKATNGAHQFQYDESWVKLPGSRPISLSMPLRQQRYQGDEAYNFFDNLLPDNPEVRNRVVARYQ
ADSTQPFDLLSCIGQDSVGALQLVAQGRPVPDVKRIECKPLSDAELEQIMTSYQQGIPLGMVREEDDFRISIAGAQEKTA
LLYLDNRWCLPHAATPTTHIIKLPIGKIESHSYSIDLSQSVENEYLCTLIAKALGLPVPHCFIMQVGKVKALAVERFDRR
YATDRSWIMRLPQEDFCQVLNVPSARKYESHGGPGIADIMTTLLGSATPEQDRYLFMKSQVLFWLLAATDGHAKNFSVFI
EPEGRFRLTPFYDILSMYPAFGGKGLHPRDAKLAMGLTATKGKKYAIEQIFPRHFYQTAKAIGFEQVQMEKIISELTDNL
DEVISIVRQQLPDTFPTEIADSILGGLSSKAQRLKR

Nucleotide

• Length: 1311 bp

>T197654 NZ_CP096532:c2047136-2046984 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACTGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATTTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9271.66 Da
• Isoelectric Point: 9.1571

>AT197654 WP_005329233.1 NZ_CP072326:2631995-2632249 [Aeromonas caviae]
MKVTSAKQLSACLKDARLSQKLSQGKVAGKVGIRQDTVSSFELNPESTKLETLFKILAALELSLDIRPRTDPAENATPGW
KEEW

Nucleotide

• Length: 255 bp

>AT197654 NZ_CP096532:c2047760-2047161 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTACTAGATGAATTAAAGAAAAATGTAG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAACAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACTGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTTGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
CGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Structures

Toxin

• AlphaFold DB: A0A2S4TP05