Detailed information of TA system TA197653

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 4524003..4525576
• Replicon: chromosome
• Accession: NZ_CP072325
• Organism: Aeromonas veronii strain 183026

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: J6598_RS20915
• Protein ID: WP_252629343.1
• Coordinates: 4524003..4525322 (-)
• Length: 440 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A1Q8D8F6
• Locus tag: J6598_RS20920
• Protein ID: WP_042013334.1
• Coordinates: 4525322..4525576 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J6598_RS20900 (J6598_20930)	4519919..4520683	+	765	WP_245098612.1	ATP-binding cassette domain-containing protein	-
J6598_RS20905 (J6598_20935)	4520718..4521602	+	885	WP_245098649.1	ABC transporter substrate-binding protein	-
J6598_RS20910 (J6598_20940)	4521599..4523581	+	1983	WP_245098610.1	Fe(3+)-hydroxamate ABC transporter permease FhuB	-
J6598_RS20915 (J6598_20945)	4524003..4525322	-	1320	WP_252629343.1	type II toxin-antitoxin system HipA family toxin	Toxin
J6598_RS20920 (J6598_20950)	4525322..4525576	-	255	WP_042013334.1	helix-turn-helix domain-containing protein	Antitoxin
J6598_RS20925 (J6598_20955)	4525746..4526174	-	429	WP_252629344.1	DUF86 domain-containing protein	-
J6598_RS20930 (J6598_20960)	4526167..4526616	-	450	WP_252629345.1	nucleotidyltransferase domain-containing protein	-
J6598_RS20935 (J6598_20965)	4527050..4527625	-	576	WP_001173919.1	recombinase family protein	-
J6598_RS20940 (J6598_20970)	4527752..4528000	-	249	WP_012585400.1	type II toxin-antitoxin system YafQ family toxin	-
J6598_RS20945 (J6598_20975)	4528260..4529273	-	1014	WP_000845048.1	class 1 integron integrase IntI1	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	cmlA1 / blaOXA-10 / ant(3'')-Ia / sul1 / dfrA10 / qacE / tet(A)	-	4527050..4544131	17081

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (150-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 440 a.a.
• Molecular weight: 49452.47 Da
• Isoelectric Point: 6.8289

>T197653 WP_252629343.1 NZ_CP072325:c4525322-4524003 [Aeromonas veronii]
MANLAVYMNGYRVGTFTKTTSGAHQFQYHESWLAQPGSRPISLSMPLRHQAYRGDEAYNFFDNLLPDNTEVRNRVVARYQ
AASTQPFDLLSCIGQDSVGALQLVTEGHDVPDVRRIDYKALSDDELEQILTSYKSGIPLGMVREQEEFRISIAGAQEKTA
LLYLDGRWYLPLNATPTTHIIKLPIGKIESHSYSIDLSQSVENEYLCTLIAKEFGLPVPHCFMMQVGQVKALAVERFDRR
YAADRSWIMRLPQEDFCQVLNVPSARKYESHGGPGITDIMKTLLGSATPEQDRYLFMKSQVLFWLLAATDGHAKNFSVFI
EPEGRFRLTPFYDILSVYPVFGGRGLNRRDAKLAMGLASSKGKKYAIEQIFPRHFFQTAKAVGFERSAMEEILTELANSV
DDVIERVIQQLPAGFPDAISSTILEGLKARSARLIKGWD

Nucleotide

• Length: 1320 bp

>T197653 NZ_CP096532:c965209-965021 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9323.64 Da
• Isoelectric Point: 7.9834

>AT197653 WP_042013334.1 NZ_CP072325:c4525576-4525322 [Aeromonas veronii]
MKVTSAKQLSACIKDARLSQKLSQGKVAEKVGIRQDTVSSFELNPESTKLETLFKILASLELSLDIKPRNESSESPASGW
KEEW

Nucleotide

• Length: 255 bp

>AT197653 NZ_CP096532:c965497-965237 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Structures

Antitoxin

• AlphaFold DB: A0A1Q8D8F6