197643

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 3141826..3142493 Replicon chromosome
Accession NZ_CP072322
Organism Escherichia coli strain EC-JS426

Toxin (Protein)


Gene name ypjF Uniprot ID E1IS66
Locus tag J6247_RS15005 Protein ID WP_000856973.1
Coordinates 3141826..3142146 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID E1IS67
Locus tag J6247_RS15010 Protein ID WP_000052843.1
Coordinates 3142167..3142493 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J6247_RS14985 (3137504) 3137504..3137797 - 294 WP_000805509.1 protein YicS -
J6247_RS14990 (3138019) 3138019..3138837 + 819 WP_000779426.1 lipoprotein NlpA -
J6247_RS14995 (3138841) 3138841..3139764 - 924 WP_000535971.1 carboxylate/amino acid/amine transporter -
J6247_RS15000 (3139875) 3139875..3141059 - 1185 WP_001172876.1 sugar efflux transporter -
J6247_RS24480 (3141456) 3141456..3141617 - 162 Protein_2950 RhuM family protein -
J6247_RS15005 (3141826) 3141826..3142146 - 321 WP_000856973.1 TA system toxin CbtA family protein Toxin
J6247_RS15010 (3142167) 3142167..3142493 - 327 WP_000052843.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
J6247_RS15015 (3142506) 3142506..3142976 - 471 WP_001275770.1 DNA repair protein RadC -
J6247_RS15020 (3143045) 3143045..3143782 - 738 Protein_2954 DUF932 domain-containing protein -
J6247_RS15030 (3145220) 3145220..3146230 - 1011 WP_001348677.1 hypothetical protein -
J6247_RS15035 (3146292) 3146292..3146981 - 690 WP_000115588.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-98)

Antitoxin

Antitoxin CbeA

(7-107)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12080.87 Da        Isoelectric Point: 5.5873

>T197643 WP_000856973.1 NZ_CP072322:c3142146-3141826 [Escherichia coli]
MKTQPATTPQAAKPCLSPLAVWQMLLTSLLDQHYGLTLNDTPFSDETVIQKHIEAGITLADAVNFLVERYELVRIDQKGF
SVQDQEPWLTSMDVHRARFKLNVERL

Download         Length: 321 bp

>T197643 NZ_CP096528:c913987-913799 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12305.01 Da        Isoelectric Point: 6.3620

>AT197643 WP_000052843.1 NZ_CP072322:c3142493-3142167 [Escherichia coli]
MSLIPAHEWGLQREIVPRFGARLVQEGNRLHYLADRANLMGNFSDTECFKLNDAFPHFISQMESMLTTGELIPCHHHCVT
LYHNGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 327 bp

>AT197643 NZ_CP096528:c914275-914015 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A345ENE3

Antitoxin

Source ID Structure
AlphaFold DB A0A345ENE4

References