Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 2506660..2507255 Replicon chromosome
Accession NZ_CP072322
Organism Escherichia coli strain EC-JS426

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag J6247_RS12045 Protein ID WP_000239579.1
Coordinates 2506660..2507010 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag J6247_RS12050 Protein ID WP_001223208.1
Coordinates 2507004..2507255 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J6247_RS12025 (2501936) 2501936..2502958 - 1023 WP_024198507.1 ABC transporter permease -
J6247_RS12030 (2502972) 2502972..2504474 - 1503 WP_000205791.1 sugar ABC transporter ATP-binding protein -
J6247_RS12035 (2504784) 2504784..2505740 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
J6247_RS12040 (2506050) 2506050..2506580 + 531 WP_000055072.1 inorganic diphosphatase -
J6247_RS12045 (2506660) 2506660..2507010 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
J6247_RS12050 (2507004) 2507004..2507255 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
J6247_RS12055 (2507468) 2507468..2507809 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
J6247_RS12060 (2507812) 2507812..2511591 - 3780 WP_000060921.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T197640 WP_000239579.1 NZ_CP072322:c2507010-2506660 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T197640 NZ_CP096526:1854942-1855130 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT197640 WP_001223208.1 NZ_CP072322:c2507255-2507004 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT197640 NZ_CP096526:1854654-1854914 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References