Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsxAB/MqsA(antitoxin) |
| Location | 29026..29491 | Replicon | plasmid pE105-5 |
| Accession | NZ_CP072316 | ||
| Organism | Escherichia coli strain E105 | ||
Toxin (Protein)
| Gene name | TsxA | Uniprot ID | U9ZUY2 |
| Locus tag | J0O73_RS26480 | Protein ID | WP_001230707.1 |
| Coordinates | 29026..29277 (+) | Length | 84 a.a. |
Antitoxin (Protein)
| Gene name | TsxB | Uniprot ID | M7CCF8 |
| Locus tag | J0O73_RS26485 | Protein ID | WP_000801440.1 |
| Coordinates | 29264..29491 (+) | Length | 76 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J0O73_RS26455 (J0O73_26455) | 24507..25034 | - | 528 | WP_000577043.1 | DUF2726 domain-containing protein | - |
| J0O73_RS26460 (J0O73_26460) | 25169..25573 | - | 405 | WP_012421203.1 | hypothetical protein | - |
| J0O73_RS26465 (J0O73_26465) | 25586..26452 | - | 867 | WP_001353743.1 | replication initiation protein | - |
| J0O73_RS26470 (J0O73_26470) | 27867..28382 | + | 516 | WP_001025395.1 | J domain-containing protein | - |
| J0O73_RS26475 (J0O73_26475) | 28487..29029 | + | 543 | WP_001083906.1 | hypothetical protein | - |
| J0O73_RS26480 (J0O73_26480) | 29026..29277 | + | 252 | WP_001230707.1 | hypothetical protein | Toxin |
| J0O73_RS26485 (J0O73_26485) | 29264..29491 | + | 228 | WP_000801440.1 | hypothetical protein | Antitoxin |
| J0O73_RS26490 (J0O73_26490) | 29945..30244 | + | 300 | WP_000650309.1 | hypothetical protein | - |
| J0O73_RS26495 (J0O73_26495) | 30335..30685 | + | 351 | WP_000854259.1 | hypothetical protein | - |
| J0O73_RS26500 (J0O73_26500) | 30990..31238 | + | 249 | WP_000520549.1 | type II toxin-antitoxin system HicA family toxin | - |
| J0O73_RS26505 (J0O73_26505) | 31235..31582 | + | 348 | WP_000681613.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| J0O73_RS26510 (J0O73_26510) | 31943..32446 | + | 504 | WP_000781813.1 | relaxosome-coupling protein TaxA | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | mcr-1.1 | - | 1..33308 | 33308 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 84 a.a. Molecular weight: 9751.13 Da Isoelectric Point: 8.9187
>T197623 WP_001230707.1 NZ_CP072316:29026-29277 [Escherichia coli]
MRKNKGDVTYFLEKEGDNYRLTKRIKARTNVKIGNKTTKITLYDAVLNENELQHIDFTCAGLREDDETPVKNLIKEFMLN
ETR
MRKNKGDVTYFLEKEGDNYRLTKRIKARTNVKIGNKTTKITLYDAVLNENELQHIDFTCAGLREDDETPVKNLIKEFMLN
ETR
Download Length: 252 bp
>T197623 NZ_CP096274:2371333-2371440 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA
Antitoxin
Download Length: 76 a.a. Molecular weight: 8659.98 Da Isoelectric Point: 8.5105
>AT197623 WP_000801440.1 NZ_CP072316:29264-29491 [Escherichia coli]
MKPDNTPENVKKLRLKAGLTQKECSHIYGVGLRTWQKKEEVNTQNSQSLSLVEFEFLLLLAGEHPEYVLCKRESK
MKPDNTPENVKKLRLKAGLTQKECSHIYGVGLRTWQKKEEVNTQNSQSLSLVEFEFLLLLAGEHPEYVLCKRESK
Download Length: 228 bp
>AT197623 NZ_CP096274:c2371517-2371457 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | U9ZUY2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5Y6U8W9 |