197620

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsxAB/MqsA(antitoxin)
Location 2856..3364 Replicon plasmid pE105-2
Accession NZ_CP072313
Organism Escherichia coli strain E105

Toxin (Protein)


Gene name TsxA Uniprot ID -
Locus tag J0O73_RS24610 Protein ID WP_052962079.1
Coordinates 3110..3364 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name TsxB Uniprot ID -
Locus tag J0O73_RS24605 Protein ID WP_052962080.1
Coordinates 2856..3113 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J0O73_RS24580 (J0O73_24580) 80..382 - 303 WP_072120077.1 CcgAII protein -
J0O73_RS24585 (J0O73_24585) 459..692 - 234 WP_052962084.1 hypothetical protein -
J0O73_RS24590 (J0O73_24590) 1119..1409 - 291 WP_231239181.1 hypothetical protein -
J0O73_RS24595 (J0O73_24595) 1711..2061 - 351 WP_052962082.1 hypothetical protein -
J0O73_RS24600 (J0O73_24600) 2153..2452 - 300 WP_077814927.1 hypothetical protein -
J0O73_RS24605 (J0O73_24605) 2856..3113 - 258 WP_052962080.1 transcriptional regulator Antitoxin
J0O73_RS24610 (J0O73_24610) 3110..3364 - 255 WP_052962079.1 hypothetical protein Toxin
J0O73_RS24615 (J0O73_24615) 3361..3903 - 543 WP_052962078.1 hypothetical protein -
J0O73_RS24620 (J0O73_24620) 4007..4522 - 516 WP_048267080.1 J domain-containing protein -
J0O73_RS24625 (J0O73_24625) 5105..5770 + 666 WP_052962077.1 ParA family protein -
J0O73_RS24630 (J0O73_24630) 5843..6082 + 240 WP_052962076.1 hypothetical protein -
J0O73_RS24635 (J0O73_24635) 6237..6491 + 255 WP_052962075.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
J0O73_RS24640 (J0O73_24640) 6491..6907 + 417 WP_052962074.1 type II toxin-antitoxin system VapC family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..36351 36351


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(8-37)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9923.49 Da        Isoelectric Point: 9.9168

>T197620 WP_052962079.1 NZ_CP072313:c3364-3110 [Escherichia coli]
MRKNKGRLTYYLEMIDEKYHFVKKISSYSKVYTEGKTKTTKRTLSELVFNENEVGAIDFTKNGLKPVDKSILLTMMKEYK
ENET

Download         Length: 255 bp

>T197620 NZ_CP096274:c958949-958698 [Staphylococcus aureus]
ATGAACAACCGCGAACAAATCGAACAATCAGTGATCAGTGCTAGTGCGTATAACGGCAATGACACAGAGGGATTGCTAAA
AGAGATTGAGGACGTTTATAAGAAAGCGCAAGCGTTTGATGAAATACTTGAGGGTTTACCTAATGCTATGCAAGATGCAC
TCAAAGAAGATATTGGTCTTGATGAAGCAGTAGGAATTATGACGGGGCAAGTTGTCTATAAATATGAGGAGGAACAGGAA
AATGAGTATTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9782.25 Da        Isoelectric Point: 7.8841

>AT197620 WP_052962080.1 NZ_CP072313:c3113-2856 [Escherichia coli]
MTIENTPENIKKLRKKIGLTQTECGEIFGVGLSTWQKKEAKTHNQLNLSKGEFEYLLLLAGEHPEYVLCKRGNMTHNEIN
EQLRP

Download         Length: 258 bp

>AT197620 NZ_CP096274:c958708-958535 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References