Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-YafN |
| Location | 60216..60751 | Replicon | plasmid pE105-1 |
| Accession | NZ_CP072312 | ||
| Organism | Escherichia coli strain E105 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | J0O73_RS24465 | Protein ID | WP_001270421.1 |
| Coordinates | 60464..60751 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | L4J0V6 |
| Locus tag | J0O73_RS24460 | Protein ID | WP_001132895.1 |
| Coordinates | 60216..60467 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J0O73_RS24430 (J0O73_24430) | 55424..55729 | - | 306 | WP_032163448.1 | hypothetical protein | - |
| J0O73_RS24435 (J0O73_24435) | 55733..56150 | - | 418 | Protein_60 | hypothetical protein | - |
| J0O73_RS24440 (J0O73_24440) | 56073..57193 | + | 1121 | Protein_61 | DUF4113 domain-containing protein | - |
| J0O73_RS24445 (J0O73_24445) | 57334..58296 | - | 963 | WP_000756329.1 | ParB family protein | - |
| J0O73_RS24450 (J0O73_24450) | 58293..59498 | - | 1206 | WP_000817643.1 | AAA family ATPase | - |
| J0O73_RS24455 (J0O73_24455) | 59869..60042 | + | 174 | WP_001435278.1 | hypothetical protein | - |
| J0O73_RS24460 (J0O73_24460) | 60216..60467 | + | 252 | WP_001132895.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| J0O73_RS24465 (J0O73_24465) | 60464..60751 | + | 288 | WP_001270421.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| J0O73_RS24470 (J0O73_24470) | 60753..61158 | + | 406 | Protein_67 | integrase core domain-containing protein | - |
| J0O73_RS24475 (J0O73_24475) | 61804..62781 | + | 978 | WP_000361617.1 | RepB family plasmid replication initiator protein | - |
| J0O73_RS24480 (J0O73_24480) | 63065..63805 | - | 741 | WP_001066926.1 | tyrosine-type recombinase/integrase | - |
| J0O73_RS24485 (J0O73_24485) | 63929..64048 | - | 120 | Protein_70 | serine/threonine protein kinase | - |
| J0O73_RS27365 | 64120..64382 | + | 263 | Protein_71 | epoxyqueuosine reductase QueH | - |
| J0O73_RS24495 (J0O73_24495) | 64592..64945 | - | 354 | WP_001368923.1 | hypothetical protein | - |
| J0O73_RS24500 (J0O73_24500) | 65169..65348 | + | 180 | WP_000526860.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | exeG / exeE / stcE / hlyD / hlyB / hlyA / hlyC | 1..84178 | 84178 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11244.27 Da Isoelectric Point: 10.4703
>T197619 WP_001270421.1 NZ_CP072312:60464-60751 [Escherichia coli]
MRYQVKFREDALKEWQKLDKTIQQQFAKKLKKCCDNPHIPSAKLRGIKDCYKIKLRASGFRLVYQVIDEQLIIAVVAVGK
RERSDVYNLASERMR
MRYQVKFREDALKEWQKLDKTIQQQFAKKLKKCCDNPHIPSAKLRGIKDCYKIKLRASGFRLVYQVIDEQLIIAVVAVGK
RERSDVYNLASERMR
Download Length: 288 bp
>T197619 NZ_CP096274:121211-121363 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGACTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAAAATTCTGAAGAAGACAGTCAGTAA
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGACTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAAAATTCTGAAGAAGACAGTCAGTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9178.47 Da Isoelectric Point: 4.2108
>AT197619 WP_001132895.1 NZ_CP072312:60216-60467 [Escherichia coli]
MPNIILSDTSASVSELKKNPMATVSAGDGFPVAILNRNQPAFYCVPAELYEKMLDALDDQELVKLVAERSNQPLHDVDLD
KYL
MPNIILSDTSASVSELKKNPMATVSAGDGFPVAILNRNQPAFYCVPAELYEKMLDALDDQELVKLVAERSNQPLHDVDLD
KYL
Download Length: 252 bp
>AT197619 NZ_CP096274:120587-121186 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|