Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 7039..7586 Replicon plasmid pE105-1
Accession NZ_CP072312
Organism Escherichia coli strain E105

Toxin (Protein)


Gene name parE Uniprot ID G7QEJ9
Locus tag J0O73_RS24175 Protein ID WP_001384452.1
Coordinates 7039..7317 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q4FIL6
Locus tag J0O73_RS24180 Protein ID WP_000079945.1
Coordinates 7317..7586 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J0O73_RS24170 (J0O73_24170) 5616..6803 + 1188 WP_044864810.1 IS91 family transposase -
J0O73_RS24175 (J0O73_24175) 7039..7317 - 279 WP_001384452.1 type II toxin-antitoxin system toxin YacB Toxin
J0O73_RS24180 (J0O73_24180) 7317..7586 - 270 WP_000079945.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
J0O73_RS24185 (J0O73_24185) 7641..7799 - 159 WP_000841008.1 hypothetical protein -
J0O73_RS24190 (J0O73_24190) 8501..9332 - 832 Protein_9 incFII family plasmid replication initiator RepA -
J0O73_RS27350 9351..9529 - 179 Protein_10 plasmid copy control protein CopA -
J0O73_RS24200 (J0O73_24200) 9644..9892 - 249 WP_044864812.1 replication regulatory protein RepA -
J0O73_RS24205 (J0O73_24205) 10121..10414 - 294 Protein_12 hypothetical protein -
J0O73_RS24210 (J0O73_24210) 10727..10870 - 144 Protein_13 IS3 family transposase -
J0O73_RS24215 (J0O73_24215) 10996..11397 - 402 WP_001222322.1 GspS family T2SS pilot lipoprotein variant EptO -
J0O73_RS24220 (J0O73_24220) 11491..12207 - 717 WP_101981710.1 A24 family peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - exeG / exeE / stcE / hlyD / hlyB / hlyA / hlyC 1..84178 84178


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10762.38 Da        Isoelectric Point: 8.4615

>T197618 WP_001384452.1 NZ_CP072312:c7317-7039 [Escherichia coli]
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

>T197618 NZ_CP096274:20169-20345 [Staphylococcus aureus]
TTGGATAGGTGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10180.52 Da        Isoelectric Point: 8.8735

>AT197618 WP_000079945.1 NZ_CP072312:c7586-7317 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLGRGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp

>AT197618 NZ_CP096274:c20507-20333 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CL36

Antitoxin

Source ID Structure
AlphaFold DB Q4FIL6

References