Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1329148..1329833 Replicon chromosome
Accession NZ_CP072309
Organism Agrobacterium tumefaciens strain 6N2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag AT6N2_RS20350 Protein ID WP_209091067.1
Coordinates 1329435..1329833 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag AT6N2_RS20345 Protein ID WP_209091066.1
Coordinates 1329148..1329438 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AT6N2_RS20340 (AT6N2_L1492) 1324439..1329106 + 4668 WP_233282599.1 glutamate synthase large subunit -
AT6N2_RS20345 (AT6N2_L1493) 1329148..1329438 + 291 WP_209091066.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
AT6N2_RS20350 (AT6N2_L1494) 1329435..1329833 + 399 WP_209091067.1 type II toxin-antitoxin system VapC family toxin Toxin
AT6N2_RS20355 (AT6N2_L1495) 1329854..1331308 + 1455 WP_144576706.1 glutamate synthase subunit beta -
AT6N2_RS20360 (AT6N2_L1496) 1331381..1332736 - 1356 WP_144576705.1 HAMP domain-containing sensor histidine kinase -
AT6N2_RS20365 (AT6N2_L1497) 1332733..1333407 - 675 WP_209091068.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-123)

Antitoxin

SpoVT-AbrB domain

(20-58)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14413.54 Da        Isoelectric Point: 4.9405

>T197613 WP_209091067.1 NZ_CP072309:1329435-1329833 [Agrobacterium tumefaciens]
MSYLLDTNVISDLIRNPEGEAARRVAKLSPGELKTSLIVAAELRYGVAKKGSARLANLVETVLADFEVLPWEAPADLHYA
AVRDGLSRSGQPIGDMDMLIAAHALSLDTVLVSDNEKEFSRVPGLKIENWLR

Download         Length: 399 bp

>T197613 NZ_CP096272:2371333-2371440 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 11211.13 Da        Isoelectric Point: 8.7657

>AT197613 WP_209091066.1 NZ_CP072309:1329148-1329438 [Agrobacterium tumefaciens]
MTKREMTMFPMPKERKAKIFKNGRSRAVRIPSDFDLPVDEVIIRQERDGLITIHPARPRRSPAELVEWLRESALIGKELP
QIEDLPLRPIDLDLPE

Download         Length: 291 bp

>AT197613 NZ_CP096272:c2371517-2371457 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References