Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 777604..778268 Replicon chromosome
Accession NZ_CP072309
Organism Agrobacterium tumefaciens strain 6N2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag AT6N2_RS17700 Protein ID WP_209090475.1
Coordinates 777861..778268 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag AT6N2_RS17695 Protein ID WP_209090473.1
Coordinates 777604..777864 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AT6N2_RS17665 (AT6N2_L0856) 773366..773602 + 237 WP_209090467.1 TraC family protein -
AT6N2_RS17670 (AT6N2_L0857) 773643..773882 + 240 WP_209090468.1 conjugal transfer protein TraD -
AT6N2_RS17675 (AT6N2_L0858) 773873..775792 + 1920 WP_209090469.1 Ti-type conjugative transfer system protein TraG -
AT6N2_RS17680 (AT6N2_L0859) 775833..776129 + 297 WP_209090470.1 metalloregulator ArsR/SmtB family transcription factor -
AT6N2_RS17685 776598..776852 + 255 WP_209090471.1 WGR domain-containing protein -
AT6N2_RS17690 (AT6N2_L0862) 776982..777260 + 279 WP_209090472.1 HU family DNA-binding protein -
AT6N2_RS17695 (AT6N2_L0863) 777604..777864 + 261 WP_209090473.1 antitoxin Antitoxin
AT6N2_RS17700 (AT6N2_L0864) 777861..778268 + 408 WP_209090475.1 type II toxin-antitoxin system VapC family toxin Toxin
AT6N2_RS17705 (AT6N2_L0866) 778626..779639 - 1014 WP_209090477.1 P-type DNA transfer ATPase VirB11 -
AT6N2_RS17710 (AT6N2_L0867) 779648..780820 - 1173 WP_209090479.1 type IV secretion system protein VirB10 -
AT6N2_RS17715 (AT6N2_L0868) 780829..781686 - 858 WP_209090481.1 P-type conjugative transfer protein VirB9 -
AT6N2_RS17720 (AT6N2_L0869) 781683..782354 - 672 WP_209090482.1 virB8 family protein -
AT6N2_RS17725 (AT6N2_L0870) 782356..782637 - 282 WP_209090483.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 671019..810714 139695


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-126)

Antitoxin

SpoVT-AbrB domain

(8-53)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14711.86 Da        Isoelectric Point: 6.2280

>T197612 WP_209090475.1 NZ_CP072309:777861-778268 [Agrobacterium tumefaciens]
VISHLLDTNAVIALIGRRSDKLANRVLQNAEGTIGLPSIVAHELYFGAQKSAKVQHNLETLRLLFSDFPILDFDQRDAFV
AGEIRAALAVKGTPIGPYDVLIAGQAKARGLMLVTNNLGEFSRVDGLRVEDWSTE

Download         Length: 408 bp

>T197612 NZ_CP096272:2339692-2339958 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATCCTTATTTAAAGAAGAC
ATTTATAGAAATTGTTGAGACTTTAAAAAATGATCCTTATAAAATAACACAATCCTTTGAAAAACTAGAACCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCTTCAGCACAGGGTCGTCTATACCATAGATGATCGAAATAAAGTAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9707.94 Da        Isoelectric Point: 5.6921

>AT197612 WP_209090473.1 NZ_CP072309:777604-777864 [Agrobacterium tumefaciens]
MPHVARVFQSGNSQAVRLPKEFRFDVDSVEITQEGDALILRPHIERGEAWSSLKAAMARSVSDDFMKEGRDQPKPQDRPA
IDTVFP

Download         Length: 261 bp

>AT197612 NZ_CP096272:2339435-2339692 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGTAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATGT
ATCTTGTATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAGTAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References