Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 1437077..1437557 Replicon chromosome
Accession NZ_CP072308
Organism Agrobacterium tumefaciens strain 6N2

Toxin (Protein)


Gene name pasB Uniprot ID -
Locus tag AT6N2_RS07220 Protein ID WP_144575703.1
Coordinates 1437288..1437557 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID A0A176XG90
Locus tag AT6N2_RS07215 Protein ID WP_063947698.1
Coordinates 1437077..1437304 (+) Length 76 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AT6N2_RS07185 1432184..1432549 + 366 WP_209089535.1 hypothetical protein -
AT6N2_RS07190 (AT6N2_C1808) 1432606..1433052 + 447 WP_063947703.1 DoxX family protein -
AT6N2_RS07195 (AT6N2_C1809) 1433115..1433807 - 693 WP_063947702.1 ATP phosphoribosyltransferase -
AT6N2_RS07200 (AT6N2_C1810) 1433804..1434928 - 1125 WP_144575698.1 ATP phosphoribosyltransferase regulatory subunit -
AT6N2_RS07205 (AT6N2_C1811) 1434945..1435313 - 369 WP_144575699.1 VOC family protein -
AT6N2_RS07210 (AT6N2_C1812) 1435318..1436841 - 1524 WP_209089536.1 histidine--tRNA ligase -
AT6N2_RS07215 (AT6N2_C1813) 1437077..1437304 + 228 WP_063947698.1 DUF6290 family protein Antitoxin
AT6N2_RS07220 (AT6N2_C1815) 1437288..1437557 + 270 WP_144575703.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AT6N2_RS07225 (AT6N2_C1816) 1437564..1438328 + 765 WP_209089537.1 hypothetical protein -
AT6N2_RS07230 (AT6N2_C1817) 1438354..1439271 - 918 WP_209089538.1 LysR family transcriptional regulator -
AT6N2_RS07235 (AT6N2_C1819) 1439353..1440396 + 1044 WP_209089540.1 YeiH family protein -
AT6N2_RS07240 (AT6N2_C1820) 1440411..1440854 - 444 WP_209089543.1 hypothetical protein -
AT6N2_RS07245 (AT6N2_C1821) 1440851..1441480 - 630 WP_144575711.1 DNA-3-methyladenine glycosylase I -
AT6N2_RS07250 (AT6N2_C1822) 1441715..1442491 + 777 WP_209089546.1 L,D-transpeptidase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 90 a.a.        Molecular weight: 10713.39 Da        Isoelectric Point: 9.9415

>T197610 WP_144575703.1 NZ_CP072308:1437288-1437557 [Agrobacterium tumefaciens]
VIWTIEYHTLVQKEMRKINPEVRRRIRSFLHERLAALDDPRQTGAALQGSELGNFWRYRVGDYRIICDIQDHKLVVLVVE
IGHRREIYR

Download         Length: 270 bp

>T197610 NZ_CP096272:c958949-958698 [Staphylococcus aureus]
ATGAACAACCGCGAACAAATCGAACAATCAGTGATCAGTGCTAGTGCGTATAACGGCAATGACACAGAGGGATTGCTAAA
AGAGATTGAGGACGTTTATAAGAAAGCGCAAGCGTTTGATGAAATACTTGAGGGTTTACCTAATGCTATGCAAGATGCAC
TCAAAGAAGATATTGGTCTTGATGAAGCAGTAGGAATTATGACGGGGCAAGTTGTCTATAAATATGAGGAGGAACAGGAA
AATGAGTATTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8923.95 Da        Isoelectric Point: 4.7254

>AT197610 WP_063947698.1 NZ_CP072308:1437077-1437304 [Agrobacterium tumefaciens]
MSKQTAIRLPDETYERLKALSERTGRTSAYYIREAIEKHIEDMEDLYLAEEATRRIQRGESKVISAEEFWRDLDN

Download         Length: 228 bp

>AT197610 NZ_CP096272:c958708-958535 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A176XG90

References