Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 999544..1000175 Replicon chromosome
Accession NZ_CP072308
Organism Agrobacterium tumefaciens strain 6N2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag AT6N2_RS05015 Protein ID WP_209088947.1
Coordinates 999544..999942 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag AT6N2_RS05020 Protein ID WP_209088950.1
Coordinates 999942..1000175 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AT6N2_RS05000 (AT6N2_C1238) 996703..997650 + 948 WP_063951080.1 peptidylprolyl isomerase -
AT6N2_RS05005 (AT6N2_C1240) 997677..998699 + 1023 WP_209088941.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
AT6N2_RS05010 (AT6N2_C1241) 998699..999529 + 831 WP_209088944.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
AT6N2_RS05015 (AT6N2_C1242) 999544..999942 - 399 WP_209088947.1 type II toxin-antitoxin system VapC family toxin Toxin
AT6N2_RS05020 (AT6N2_C1243) 999942..1000175 - 234 WP_209088950.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
AT6N2_RS05025 (AT6N2_C1244) 1000302..1000964 - 663 WP_063951076.1 guanylate kinase -
AT6N2_RS05030 (AT6N2_C1245) 1000969..1001856 - 888 WP_063951075.1 YicC/YloC family endoribonuclease -
AT6N2_RS05035 (AT6N2_C1247) 1001924..1003144 - 1221 WP_063951074.1 endolytic transglycosylase MltG -
AT6N2_RS05040 (AT6N2_C1248) 1003468..1004730 - 1263 WP_144574980.1 beta-ketoacyl-ACP synthase II -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(7-56)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14909.12 Da        Isoelectric Point: 6.8444

>T197609 WP_209088947.1 NZ_CP072308:c999942-999544 [Agrobacterium tumefaciens]
MLRYMLDTNICIYVMKTYPPDLRDKFNSLADELCISSITLGELYYGAEKSARRHDNLNAVENFCARLEVLPFAEKAASHY
GQIRAELARAGTPCGAHDMQIGGHARSEGLIVVTNNMREFVRMPGLRVENWV

Download         Length: 399 bp

>T197609 NZ_CP096272:121211-121363 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGACTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAAAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8816.05 Da        Isoelectric Point: 5.8235

>AT197609 WP_209088950.1 NZ_CP072308:c1000175-999942 [Agrobacterium tumefaciens]
MATSTIFTSNRSQAVRLPKNVAFPDDVHKVEILKVGLTRIIVPYGKRWDDLFLTGPRVTEDFLPSREEPPSEEREAF

Download         Length: 234 bp

>AT197609 NZ_CP096272:120587-121186 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References