Detailed information of TA system TA197607

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 1853380..1855016
• Replicon: chromosome
• Accession: NZ_CP072305
• Organism: Acinetobacter baumannii strain KSK Sensitive

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A1E3M7C1
• Locus tag: J6I88_RS08815
• Protein ID: WP_000737056.1
• Coordinates: 1853380..1854711 (+)
• Length: 444 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: J6I88_RS08820
• Protein ID: WP_001101308.1
• Coordinates: 1854708..1855016 (+)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J6I88_RS08795 (J6I88_08795)	1849695..1850855	+	1161	WP_001044492.1	hypothetical protein	-
J6I88_RS08800 (J6I88_08800)	1850982..1851953	+	972	WP_109104914.1	5'/3'-nucleotidase SurE	-
J6I88_RS08805 (J6I88_08805)	1851965..1852609	+	645	WP_000817301.1	hypothetical protein	-
J6I88_RS08810 (J6I88_08810)	1852644..1853084	-	441	WP_000193135.1	HD domain-containing protein	-
J6I88_RS08815 (J6I88_08815)	1853380..1854711	+	1332	WP_000737056.1	HipA domain-containing protein	Toxin
J6I88_RS08820 (J6I88_08820)	1854708..1855016	+	309	WP_001101308.1	helix-turn-helix domain-containing protein	Antitoxin
J6I88_RS08825 (J6I88_08825)	1855742..1856293	+	552	WP_005135235.1	TetR/AcrR family transcriptional regulator	-
J6I88_RS08830 (J6I88_08830)	1856509..1857129	+	621	WP_000658761.1	hypothetical protein	-
J6I88_RS08835 (J6I88_08835)	1857147..1858229	+	1083	WP_001095788.1	XRE family transcriptional regulator	-
J6I88_RS08840 (J6I88_08840)	1858271..1858786	+	516	WP_000914805.1	hypothetical protein	-
J6I88_RS08845 (J6I88_08845)	1858934..1859452	+	519	WP_000651611.1	GNAT family N-acetyltransferase	-
J6I88_RS18765	1859433..1859564	+	132	Protein_1729	TetR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (167-359)

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-83)

Sequences

Toxin

Protein

• Length: 444 a.a.
• Molecular weight: 51189.16 Da
• Isoelectric Point: 4.7456

>T197607 WP_000737056.1 NZ_CP072305:1853380-1854711 [Acinetobacter baumannii]
MKKLTIQALLNKNWIDIAELKLLEPKLGSASASELEYELDYAIQYLDRRDEHACSLSLPVQILIKHESDTWFGFLDDIVP
SGAARRYWVNYLDLQRLTYAEQESILLEKGGMAPVGNLRIKEALPPLNPESTLHLRYFSKEDVAERNIDFLEYAQQMGAI
SGGATGAGGEAPKLLIRVSPEQKVWIDTYQEQFDQPDQHYLVKFPRNNRSEIDCDILRAEYYYYQILNELGFNTIETTQM
QLIEGTKYPSLWLPRFDTEWCDQYWHRYGLESVYSVLNKSSGSHLNHFEVIEDLCRLLTSIDSDFDVPQFICEWLQRDLL
NIIFGNSDNHGRNTSFIKKSGKIYLSPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWAQITQKLAPWCDPDLSLATLR
TLANNLLGLKQRLVDKGVPKQIIEMPALSFDYIEAKLKRWELL

Nucleotide

• Length: 1332 bp

>T197607 NZ_CP096267:32774-33106 [Klebsiella quasipneumoniae]
ATGGTATCTCGTTTTGTGCCGGATGCTGGCGACCTTATCTGGATAAATTTTGATCCCGTGGAAGGACATGAGCAAGGAGG
GCATCGCCCCGCAGTCGTGCTGAGTCCGTTTGCATACAACAACAAAACAGGTTTGTTGCTGTGCGTACCTTGCACAACAA
AAGTAAAAGGCTATCCCTTTGAAGTTGAATTGCCAGGAGAACGCGATGGTGTAGCTCTTGCAGATCAAATAACGTGTGTA
GACTGGCGAGCCAGAAAAGTAGAAAAGAAGGGAAAGGTTGCCACCGGAGAATTGTCAGAAATCAGAGCTAAAGCAAAAGC
CTTAATCGGTTGA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11626.55 Da
• Isoelectric Point: 9.9701

>AT197607 WP_001101308.1 NZ_CP072305:1854708-1855016 [Acinetobacter baumannii]
MNVKNQPQDRQQILIDLYKQYLLSEITLGQLLSYLRKNVLGLSQEQYANLVGISRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVSKIIKPNE

Nucleotide

• Length: 309 bp

>AT197607 NZ_CP096267:32529-32774 [Klebsiella quasipneumoniae]
ATGTCACAGGCAACGTTCAAGAAATGGGGTAACCAGGCAGGAATTCGTTTTCCGGCAGCGGTGATGAAAGCAGCAGCGCT
TAACGTAGATGATACGGTTGATATTGAGGTACAGGAAGGGCGGATTGTACTCATACCAACGAAAGAAAAGACCTATTCAC
TCGATGCCTTATTATCCGGCATCACCGAAGAAAACATGCATAACAAAGCTGACTTCGGCAAACCGACAGGGAAGGAAATG
CTCTGA

Structures

Toxin

• AlphaFold DB: A0A1E3M7C1