Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 456379..457032 Replicon chromosome
Accession NZ_CP072305
Organism Acinetobacter baumannii strain KSK Sensitive

Toxin (Protein)


Gene name cptA Uniprot ID A0A1E3M967
Locus tag J6I88_RS02250 Protein ID WP_009518132.1
Coordinates 456643..457032 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag J6I88_RS02245 Protein ID WP_001288210.1
Coordinates 456379..456636 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J6I88_RS02225 (J6I88_02225) 451894..452901 + 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -
J6I88_RS02230 (J6I88_02230) 452920..453297 + 378 WP_001216380.1 50S ribosomal protein L17 -
J6I88_RS02235 (J6I88_02235) 453479..454969 + 1491 WP_000415133.1 NAD(P)/FAD-dependent oxidoreductase -
J6I88_RS02240 (J6I88_02240) 455019..456191 - 1173 WP_001190550.1 acyl-CoA dehydrogenase family protein -
J6I88_RS02245 (J6I88_02245) 456379..456636 + 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
J6I88_RS02250 (J6I88_02250) 456643..457032 + 390 WP_009518132.1 hypothetical protein Toxin
J6I88_RS02255 (J6I88_02255) 457802..458887 + 1086 WP_000049106.1 hypothetical protein -
J6I88_RS02260 (J6I88_02260) 458966..459532 + 567 WP_000651536.1 rhombosortase -
J6I88_RS02265 (J6I88_02265) 459720..461915 + 2196 WP_001158905.1 TRAP transporter large permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15720.03 Da        Isoelectric Point: 10.4623

>T197605 WP_009518132.1 NZ_CP072305:456643-457032 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFINFIFFLKRPQLAQIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKKLTSIIWFDQMSLTEWKKLKTLEKLY

Download         Length: 390 bp

>T197605 NZ_CP096266:61065-61370 [Klebsiella quasipneumoniae]
ATGCAGTTTAAGGTTTATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGACGGATGGTGATCCCGCTGGCCAGCGCCCGGCTGCTGTCGGATAAGGTTTCCCGTGAACTCTATCCGGTGG
TGCACATCGGGGACGAAAGCTACCGCCTGATGACCACGGACATGGCCAGCGTCACGTCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCAGCCACCGGGAAAATGACATCAAAAATGCGATAAACCTGATGTTCTGGGGAATTTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT197605 WP_001288210.1 NZ_CP072305:456379-456636 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT197605 NZ_CP096266:60845-61063 [Klebsiella quasipneumoniae]
ATGAAGCAGCGCATCACTGTCACCATAGACAGCGACAGTTATCAGTTACTGAAATCCGCAGACGTCAATATCTCCGCCCT
GGTGAACAGGGCCATGCAGAATGAGGCCCGTCGTCTGCGTTCCGAACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCCG
AGGTTGCCCGCTTTATTGAGATGAACGGTTCATTCGCCGACGAAAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1E3M967

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References