Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 461340..461993 Replicon chromosome
Accession NZ_CP072300
Organism Acinetobacter baumannii strain KSK20

Toxin (Protein)


Gene name cptA Uniprot ID A0A246A3V9
Locus tag J6I82_RS02260 Protein ID WP_002054941.1
Coordinates 461604..461993 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag J6I82_RS02255 Protein ID WP_001288210.1
Coordinates 461340..461597 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J6I82_RS02235 (J6I82_02235) 456855..457862 + 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -
J6I82_RS02240 (J6I82_02240) 457881..458258 + 378 WP_001216380.1 50S ribosomal protein L17 -
J6I82_RS02245 (J6I82_02245) 458440..459930 + 1491 WP_000415133.1 NAD(P)/FAD-dependent oxidoreductase -
J6I82_RS02250 (J6I82_02250) 459980..461152 - 1173 WP_001190546.1 acyl-CoA dehydrogenase family protein -
J6I82_RS02255 (J6I82_02255) 461340..461597 + 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
J6I82_RS02260 (J6I82_02260) 461604..461993 + 390 WP_002054941.1 hypothetical protein Toxin
J6I82_RS02265 (J6I82_02265) 462763..463848 + 1086 WP_000049106.1 hypothetical protein -
J6I82_RS02270 (J6I82_02270) 463926..464492 + 567 WP_000651536.1 rhombosortase -
J6I82_RS02275 (J6I82_02275) 464680..466875 + 2196 WP_001158905.1 TRAP transporter large permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15616.87 Da        Isoelectric Point: 10.2790

>T197599 WP_002054941.1 NZ_CP072300:461604-461993 [Acinetobacter baumannii]
MINHLNFKLKYSHFSIIFQFFIGLSLAILFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYHSQNTI
SRVKILKVIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T197599 NZ_CP096263:c1141121-1140903 [Klebsiella quasipneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGCCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAACAAATATGAACTTTCTGATAATGAGCTGGCGGTATTTTACTCAGCCGCCGATCATCGTCTGGCTGAAC
TGACCATGAATAAGCTGTACGATAAGATCCCGACGTCCGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT197599 WP_001288210.1 NZ_CP072300:461340-461597 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT197599 NZ_CP096263:c1141522-1141148 [Klebsiella quasipneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATCGCACAACTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACATCGGCTGTCAATCTCCAGTTAAATGAACTGATCGAGC
ACATTGCCACATTCGCCCTTAATTATAAAATTAAGTACGCTGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGATACATTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAATCGGTT
ATTTCGTTGTTTTGTCAACGCCAGCCGGGAAAATCCGGCCAGTCTTTCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A246A3V9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References