Detailed information of TA system TA197596

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2954965..2955644
• Replicon: chromosome
• Accession: NZ_CP072295
• Organism: Acinetobacter baumannii strain KSK19

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: J6I63_RS14105
• Protein ID: WP_000838146.1
• Coordinates: 2955462..2955644 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: J6I63_RS14100
• Protein ID: WP_000966688.1
• Coordinates: 2954965..2955369 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J6I63_RS14090 (J6I63_14090)	2953921..2954184	-	264	WP_001275792.1	hypothetical protein	-
J6I63_RS14095 (J6I63_14095)	2954186..2954866	-	681	WP_000721572.1	hypothetical protein	-
J6I63_RS14100 (J6I63_14100)	2954965..2955369	-	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
J6I63_RS14105 (J6I63_14105)	2955462..2955644	-	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
J6I63_RS14110 (J6I63_14110)	2955970..2956485	-	516	WP_001185592.1	hypothetical protein	-
J6I63_RS14115 (J6I63_14115)	2956555..2957472	-	918	WP_000094273.1	phage tail tube protein	-
J6I63_RS14120 (J6I63_14120)	2957525..2958496	-	972	WP_032051761.1	hypothetical protein	-
J6I63_RS14125 (J6I63_14125)	2958496..2958849	-	354	WP_032051762.1	hypothetical protein	-
J6I63_RS14130 (J6I63_14130)	2958945..2959163	-	219	WP_002002228.1	hypothetical protein	-
J6I63_RS14135 (J6I63_14135)	2959165..2959563	-	399	WP_002062850.1	phage tail terminator-like protein	-
J6I63_RS14140 (J6I63_14140)	2959565..2959933	-	369	WP_001993865.1	hypothetical protein	-
J6I63_RS14145 (J6I63_14145)	2959905..2960309	-	405	WP_045544425.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2942302..2993487	51185

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T197596 WP_000838146.1 NZ_CP072295:c2955644-2955462 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T197596 NZ_CP096261:c151168-150743 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGTGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAAGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCT
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACCGCCATTGC
CGGACACGCCATCGCGGCGGGCGCCATCCTGGTGACGAATAATACAAGAGAGTTTGAGCGGGTGCCGGGTCTGGTTCTGG
AAGACTGGGTTGGCTTTGTTGAATAA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT197596 WP_000966688.1 NZ_CP072295:c2955369-2954965 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT197596 NZ_CP096261:c151395-151165 [Klebsiella pneumoniae]
ATGCGCACAGTATCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGACGAAGGACGCTTTGATCCATGA

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6