Detailed information of TA system TA197595

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 1973893..1975529
• Replicon: chromosome
• Accession: NZ_CP072295
• Organism: Acinetobacter baumannii strain KSK19

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A090B5R1
• Locus tag: J6I63_RS09470
• Protein ID: WP_045544121.1
• Coordinates: 1973893..1975224 (+)
• Length: 444 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: J6I63_RS09475
• Protein ID: WP_001101310.1
• Coordinates: 1975221..1975529 (+)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J6I63_RS09450 (J6I63_09450)	1970205..1971368	+	1164	WP_045544117.1	hypothetical protein	-
J6I63_RS09455 (J6I63_09455)	1971495..1972466	+	972	WP_087486613.1	5'/3'-nucleotidase SurE	-
J6I63_RS09460 (J6I63_09460)	1972478..1973122	+	645	WP_045544119.1	hypothetical protein	-
J6I63_RS09465 (J6I63_09465)	1973157..1973597	-	441	WP_045544120.1	HD domain-containing protein	-
J6I63_RS09470 (J6I63_09470)	1973893..1975224	+	1332	WP_045544121.1	HipA domain-containing protein	Toxin
J6I63_RS09475 (J6I63_09475)	1975221..1975529	+	309	WP_001101310.1	helix-turn-helix domain-containing protein	Antitoxin
J6I63_RS09480 (J6I63_09480)	1976252..1976800	+	549	WP_045544122.1	TetR/AcrR family transcriptional regulator	-
J6I63_RS09485 (J6I63_09485)	1976994..1978691	+	1698	WP_045544123.1	AAA family ATPase	-
J6I63_RS09490 (J6I63_09490)	1978696..1980321	+	1626	WP_045544124.1	ATP-dependent helicase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (167-359)

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-83)

Sequences

Toxin

Protein

• Length: 444 a.a.
• Molecular weight: 51189.29 Da
• Isoelectric Point: 4.9177

>T197595 WP_045544121.1 NZ_CP072295:1973893-1975224 [Acinetobacter baumannii]
MKKLTIQALLNKNWIDIAELKLLEPKLGSASASELEYELDYAIQYLDRRDEHACSLSLPVQILIKHESDTWFGFLDDIVP
SGAARRYWVNYLDLQRLTYAEQESILLEKGGMAPVGNLRIKEALPPLNPESTLHLRYFSKEDVAERNIDFLEYAQQMGAI
SGGATGAGGEAPKLLIRVSPEQKVWIDTYQEKFDQPDQHYLVKFPRNKRSEIDCDILRAEYYYYQILNELGFNTIETTQM
KLIEGTKYPSLWLPRFDTEWCDQYWHRYGLESVYSVLNKSSGSHLNHFEVIEDLCRLLTSIDSDFDVPQFVCEWLQRDLL
NIIFGNSDNHGRNTSFIKKSGKIYLSPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWAQITQKLAPWCDPDLSLATLR
TLANNLLGLKQRLVDKGVPKQIIEMPALSFDYIEAKLKRWELL

Nucleotide

• Length: 1332 bp

>T197595 NZ_CP096261:110019-110330 [Klebsiella pneumoniae]
ATGCACGTAATTTCAAAAGAGCCTTTTGAGGAAGCGGCAAAGCGATATCCCAACGATTCGTTAGCCATTCGGGCGTTGTA
CCGCTTAGTGCGCGAGACGGACTTCTCTTCTCCAGCTGAGATGCTAACTCTGATACCGAGCCTGGATAATTTTAAGTACA
GGAATAAGTGGTGGGTTTTGGATGTAGGGGGCAACAACTTAAGGGTTATCGCCTATATCAATTTCGTAAATAAGCGCTTC
TACGTGAAGCACATCGCAACCCACGCTGATTACGACAAGTTGACCCGCTATTACAGGGAGAACAAAGAATGA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11630.54 Da
• Isoelectric Point: 9.9701

>AT197595 WP_001101310.1 NZ_CP072295:1975221-1975529 [Acinetobacter baumannii]
MNVKNQTQDRQQILIDLYKQYLLSEITLGQLLSYLRKNVLGLSQEQYANLVGISRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVSKIIKPNE

Nucleotide

• Length: 309 bp

>AT197595 NZ_CP096261:110327-110746 [Klebsiella pneumoniae]
ATGATTACCGACACTGCAAAAGCCATTGAAGCAACCAAACAACTCGTAGCTGCCGTCCCCTTCCTAGGGGGCAGTTCTTC
CGAGAGCGATTACCGCGAAGCGATGGAGCTGGTGGATTATCTGATCGAGAACGACGACGAGAACCCACTTATTGACTTCC
TGGCGAGTAAGATTGCCGACTATGAAGATAACAGCCCTCGTTTCGCTGAGTTCAACAAAGCTATTGCTGAAATACCAGTC
GGCGTTGCACTTCTGCGAACCCTGATTGACCAGCACAAGCTGTCTTATTCAGACCTTAAGGATGAGATCGGATCTAAATC
ATTGGTCAGCCAAATCCTGTCAGGGCAGCGCTCTTTGACCATCACTCACATAAAAGCTCTTTCCGCGCGCTTCGGTGTAA
AACCTGAGTGGTTCCTATAA

Structures

Toxin

• AlphaFold DB: A0A090B5R1