Detailed information of TA system TA197594

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1666483..1667162
• Replicon: chromosome
• Accession: NZ_CP072295
• Organism: Acinetobacter baumannii strain KSK19

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: J6I63_RS07985
• Protein ID: WP_000838146.1
• Coordinates: 1666483..1666665 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: J6I63_RS07990
• Protein ID: WP_000966688.1
• Coordinates: 1666758..1667162 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J6I63_RS07945 (J6I63_07945)	1661563..1661931	+	369	WP_032016325.1	hypothetical protein	-
J6I63_RS07950 (J6I63_07950)	1661933..1662331	+	399	WP_045544022.1	phage tail terminator-like protein	-
J6I63_RS07955 (J6I63_07955)	1662333..1662551	+	219	WP_002132566.1	hypothetical protein	-
J6I63_RS07960 (J6I63_07960)	1662660..1663181	+	522	WP_002055493.1	SH3 domain-containing protein	-
J6I63_RS07965 (J6I63_07965)	1663278..1663631	+	354	WP_002055486.1	hypothetical protein	-
J6I63_RS07970 (J6I63_07970)	1663631..1664602	+	972	WP_045544023.1	hypothetical protein	-
J6I63_RS07975 (J6I63_07975)	1664655..1665572	+	918	WP_042774720.1	phage tail tube protein	-
J6I63_RS07980 (J6I63_07980)	1665642..1666157	+	516	WP_009517104.1	hypothetical protein	-
J6I63_RS07985 (J6I63_07985)	1666483..1666665	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
J6I63_RS07990 (J6I63_07990)	1666758..1667162	+	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
J6I63_RS07995 (J6I63_07995)	1667262..1667771	+	510	WP_000735548.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1640717..1693145	52428

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T197594 WP_000838146.1 NZ_CP072295:1666483-1666665 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T197594 NZ_CP096261:87688-88158 [Klebsiella pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
CTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACAGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGACAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAATTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATAGCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT197594 WP_000966688.1 NZ_CP072295:1666758-1667162 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT197594 NZ_CP096261:87248-87691 [Klebsiella pneumoniae]
ATGAAAACATTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
CGTAGCGCTTCTGGGCCAAATAAATGAAGGTCTGGACGGGAAGGTGGCGAACCGGATAACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCAACCACATTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGTATTATCCGCGTCATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAGGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAAACGGGAGCCTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6