Detailed information of TA system TA197588

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1666474..1667153
• Replicon: chromosome
• Accession: NZ_CP072290
• Organism: Acinetobacter baumannii strain KSK18

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: J6I51_RS07985
• Protein ID: WP_000838146.1
• Coordinates: 1666474..1666656 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: J6I51_RS07990
• Protein ID: WP_000966688.1
• Coordinates: 1666749..1667153 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J6I51_RS07945 (J6I51_07945)	1661554..1661922	+	369	WP_032016325.1	hypothetical protein	-
J6I51_RS07950 (J6I51_07950)	1661924..1662322	+	399	WP_045544022.1	phage tail terminator-like protein	-
J6I51_RS07955 (J6I51_07955)	1662324..1662542	+	219	WP_002132566.1	hypothetical protein	-
J6I51_RS07960 (J6I51_07960)	1662651..1663172	+	522	WP_002055493.1	SH3 domain-containing protein	-
J6I51_RS07965 (J6I51_07965)	1663269..1663622	+	354	WP_002055486.1	hypothetical protein	-
J6I51_RS07970 (J6I51_07970)	1663622..1664593	+	972	WP_045544023.1	hypothetical protein	-
J6I51_RS07975 (J6I51_07975)	1664646..1665563	+	918	WP_042774720.1	phage tail tube protein	-
J6I51_RS07980 (J6I51_07980)	1665633..1666148	+	516	WP_009517104.1	hypothetical protein	-
J6I51_RS07985 (J6I51_07985)	1666474..1666656	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
J6I51_RS07990 (J6I51_07990)	1666749..1667153	+	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
J6I51_RS07995 (J6I51_07995)	1667253..1667762	+	510	WP_000735548.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1636044..1693136	57092

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T197588 WP_000838146.1 NZ_CP072290:1666474-1666656 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T197588 NZ_CP096260:c3938398-3938081 [Klebsiella pneumoniae]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT197588 WP_000966688.1 NZ_CP072290:1666749-1667153 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT197588 NZ_CP096260:c3938088-3937801 [Klebsiella pneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTGGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTAACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCGACAGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6