Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 709115..709768 Replicon chromosome
Accession NZ_CP072285
Organism Acinetobacter baumannii strain KSK11

Toxin (Protein)


Gene name cptA Uniprot ID A0A246A3V9
Locus tag J6I33_RS03440 Protein ID WP_002054941.1
Coordinates 709379..709768 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag J6I33_RS03435 Protein ID WP_001288210.1
Coordinates 709115..709372 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J6I33_RS03415 (J6I33_03415) 704630..705637 + 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -
J6I33_RS03420 (J6I33_03420) 705656..706033 + 378 WP_001216380.1 50S ribosomal protein L17 -
J6I33_RS03425 (J6I33_03425) 706215..707705 + 1491 WP_000415133.1 NAD(P)/FAD-dependent oxidoreductase -
J6I33_RS03430 (J6I33_03430) 707755..708927 - 1173 WP_001190546.1 acyl-CoA dehydrogenase family protein -
J6I33_RS03435 (J6I33_03435) 709115..709372 + 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
J6I33_RS03440 (J6I33_03440) 709379..709768 + 390 WP_002054941.1 hypothetical protein Toxin
J6I33_RS03445 (J6I33_03445) 710538..711623 + 1086 WP_000049106.1 hypothetical protein -
J6I33_RS03450 (J6I33_03450) 711701..712267 + 567 WP_000651536.1 rhombosortase -
J6I33_RS03455 (J6I33_03455) 712455..714650 + 2196 WP_001158905.1 TRAP transporter large permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15616.87 Da        Isoelectric Point: 10.2790

>T197581 WP_002054941.1 NZ_CP072285:709379-709768 [Acinetobacter baumannii]
MINHLNFKLKYSHFSIIFQFFIGLSLAILFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYHSQNTI
SRVKILKVIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T197581 NZ_CP096259:122040-122372 [Providencia rettgeri]
ATGGTATCTCGATACGTACCTGATTCTGGCGATTTGATTTGGATTGACTTTGATCCAGTTGAAGGACATGAGCAGGGCGG
TCATCGTCCAGCAGTTGTCCTTAGCCCTTTTGCATACAATAATAAAGTAGGGCTCTTACTATGCGTACCATGTACAACTA
AAGGCAAAGGCTATCCATTTGAATGCGAACTCTCGAACGAAAGAGACAGCTACGCATTAGCGGATCAAGTTACATGTGTT
GACTGGAGAGCTCGTAAAGTTACTAAAAAGGGCAAAGTGGAGGCATCAGAACTGGCAGAGATAAAAGCTAAAGCAAAGGC
GTTAATAGGATAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT197581 WP_001288210.1 NZ_CP072285:709115-709372 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT197581 NZ_CP096259:121795-122040 [Providencia rettgeri]
ATGGCTCAGGTCACAGTAAAAAAATGGGGCAATAGCCCGTCTGTACGGCTTCCTGTTGCAATCATGCAAAAAGCGGCACT
TAGCGTTGATGATACGGTTGAAATAGCGGTAGAAGAAGGTCGTATCATCATTACGCCAGTTAAAGCGGTAGAATACTCAT
TAGATAATTTGTTAGCCGGTATCACACCGGAGAATATCCATGAGAAAGTAGACTTCGGAGCTCGAACAGGTAAGGAATTA
ATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A246A3V9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References