Detailed information of TA system TA197578

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2956144..2956823
• Replicon: chromosome
• Accession: NZ_CP072280
• Organism: Acinetobacter baumannii strain KSK10

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: J6F37_RS14110
• Protein ID: WP_000838146.1
• Coordinates: 2956641..2956823 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: J6F37_RS14105
• Protein ID: WP_000966688.1
• Coordinates: 2956144..2956548 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J6F37_RS14095 (J6F37_14095)	2955100..2955363	-	264	WP_001275792.1	hypothetical protein	-
J6F37_RS14100 (J6F37_14100)	2955365..2956045	-	681	WP_000721572.1	hypothetical protein	-
J6F37_RS14105 (J6F37_14105)	2956144..2956548	-	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
J6F37_RS14110 (J6F37_14110)	2956641..2956823	-	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
J6F37_RS14115 (J6F37_14115)	2957149..2957664	-	516	WP_001185592.1	hypothetical protein	-
J6F37_RS14120 (J6F37_14120)	2957734..2958651	-	918	WP_000094273.1	phage tail tube protein	-
J6F37_RS14125 (J6F37_14125)	2958704..2959675	-	972	WP_032051761.1	hypothetical protein	-
J6F37_RS14130 (J6F37_14130)	2959675..2960028	-	354	WP_032051762.1	hypothetical protein	-
J6F37_RS14135 (J6F37_14135)	2960124..2960342	-	219	WP_002002228.1	hypothetical protein	-
J6F37_RS14140 (J6F37_14140)	2960344..2960742	-	399	WP_002062850.1	phage tail terminator-like protein	-
J6F37_RS14145 (J6F37_14145)	2960744..2961112	-	369	WP_001993865.1	hypothetical protein	-
J6F37_RS14150 (J6F37_14150)	2961084..2961488	-	405	WP_045544425.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2943481..2994666	51185

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T197578 WP_000838146.1 NZ_CP072280:c2956823-2956641 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T197578 NZ_CP096258:c4334485-4334201 [Providencia rettgeri]
ATGAATACTAAATTAAAAGAATTTGATATCACTGAGTATTTAAACAGTGAAGAAGAAATACAGATGTATCTAAACGAAAT
TTTAGAGGAAGGTGACCCTAGTCTAGTTCTCGCTGCACTTGGTGATATTGCAAAGGCAAGAAATATGAGCCAATTAGCTA
AAGAAGTTGGAATGAGTCGTGAAGGTTTATATAAGGCGCTATCAGGACAGGGAAATCCAACATTTATGACGATTATAAAA
ATCGTTAATTCTCTCGGATTAAAGCTACAGTTTAAGAGTATCTAA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT197578 WP_000966688.1 NZ_CP072280:c2956548-2956144 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT197578 NZ_CP096258:c4334784-4334482 [Providencia rettgeri]
ATGATCACGGTTCTAACAACGGAATGTTTTGATAGTTGGATCAAAAACCTTAGAGATATTCGAGCTAAAACTAAAATTCT
AGTGAGAATTAGGCGGTTAAAAAATGGAAATTATGGTGATGTTCAACCCATTGGTGATGGCTTTTCGGAACTGAGGGTAC
ATGAAGGACAAGGGTATCGTGTTTACCTAAAGCAGAAAAACAATGTTATTGTAATTTTACTTTGTGGTGGGACAAAGGCA
ACGCAACAGAAGGATATCCATAAAGCTAAACTCCTTTTTGGTGAAGTTGAGGGGGAACTATGA

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6