Detailed information of TA system TA197566

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2950387..2951066
• Replicon: chromosome
• Accession: NZ_CP072270
• Organism: Acinetobacter baumannii strain KSK6

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: J6E47_RS14080
• Protein ID: WP_000838146.1
• Coordinates: 2950884..2951066 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: J6E47_RS14075
• Protein ID: WP_000966688.1
• Coordinates: 2950387..2950791 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J6E47_RS14065 (J6E47_14065)	2949343..2949606	-	264	WP_001275792.1	hypothetical protein	-
J6E47_RS14070 (J6E47_14070)	2949608..2950288	-	681	WP_000721572.1	hypothetical protein	-
J6E47_RS14075 (J6E47_14075)	2950387..2950791	-	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
J6E47_RS14080 (J6E47_14080)	2950884..2951066	-	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
J6E47_RS14085 (J6E47_14085)	2951392..2951907	-	516	WP_001185592.1	hypothetical protein	-
J6E47_RS14090 (J6E47_14090)	2951977..2952894	-	918	WP_000094273.1	phage tail tube protein	-
J6E47_RS14095 (J6E47_14095)	2952947..2953918	-	972	WP_032051761.1	hypothetical protein	-
J6E47_RS14100 (J6E47_14100)	2953918..2954271	-	354	WP_032051762.1	hypothetical protein	-
J6E47_RS14105 (J6E47_14105)	2954367..2954585	-	219	WP_002002228.1	hypothetical protein	-
J6E47_RS14110 (J6E47_14110)	2954587..2954985	-	399	WP_002062850.1	phage tail terminator-like protein	-
J6E47_RS14115 (J6E47_14115)	2954987..2955355	-	369	WP_001993865.1	hypothetical protein	-
J6E47_RS14120 (J6E47_14120)	2955327..2955731	-	405	WP_045544425.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2937724..2988909	51185

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T197566 WP_000838146.1 NZ_CP072270:c2951066-2950884 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T197566 NZ_CP096255:7577979-7578404 [Bradyrhizobium barranii subsp. apii]
GTGAACCTGCTCCTCGACACCAACGTGCTGTCGGAGGTTCAGCGGCCGGCGCCTTCCGCGAAAGTCCTGGCATGGCTCGA
TACGGTCGATGAGGATCGCGCGTTCATCAGCGTTGCCTCGATCGCCGAGCTTCGTCGCGGCATCGCCCTGCTGGACGATG
GCCGTCGGCGCGCCGCGCTGGGCGCTTGGCTCGCCCATGACCTGCCGGCTCGGTTCGCGCAGCGCATCCTGCCGATCGAC
CACGCGGTCGCTGAGCGCTGGGGCGACCTGATGGCGCAGAGCCGTCGCAATGGCGTTGCGTTGTCCGTGATGGACGGCTT
CTTTGCGGCCACCGCGCTCGCCAACGAGCTCACGCTCGTCACACGCAATGTGAAGGATTTTGCGGCCTTCGGCGTTCCGC
TGCTTGACCCATGGAGCGACGCCTAA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT197566 WP_000966688.1 NZ_CP072270:c2950791-2950387 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT197566 NZ_CP096255:7577701-7577982 [Bradyrhizobium barranii subsp. apii]
ATGACAGACCGCAGCACCGCCCCCGATTCGCCCCCGACTGACACGTGGACGCTCGCCAATGCCAAGGCGCGCCTTTCCGA
GGTGGTCGATCGCGCCCAAACTGGCCCCCAGATCATCACCCGACACGGCAGACCCAATGCGGTTGTCGTTTCCGCGGATG
AATGGGCGCGAAAGACGGCACGCAAAGGCACGCTGGCCGAATTCCTGCTGGCTTCGCCGCTGCGCGGTGCCGACCTCGAA
CTTGAACGGGTGCAGGACGAACCGCGCGACGAGATGCCGTGA

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6