Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) EcnAB/-
Location 4600565..4600926 Replicon chromosome
Accession NZ_CP072268
Organism Xanthomonas euvesicatoria pv. alfalfae strain CFBP3836

Toxin (Protein)


Gene name EcnB Uniprot ID M4UGA1
Locus tag XeaCFBP3836p_RS19660 Protein ID WP_005914328.1
Coordinates 4600565..4600699 (-) Length 45 a.a.

Antitoxin (Protein)


Gene name EcnA Uniprot ID Q3BN31
Locus tag XeaCFBP3836p_RS19665 Protein ID WP_011348912.1
Coordinates 4600774..4600926 (-) Length 51 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XeaCFBP3836p_RS19645 (XeaCFBP3836p_19645) 4597599..4598543 - 945 WP_008576427.1 MBL fold metallo-hydrolase -
XeaCFBP3836p_RS19650 (XeaCFBP3836p_19650) 4598672..4599961 - 1290 WP_029820636.1 tryptophan--tRNA ligase -
XeaCFBP3836p_RS19655 (XeaCFBP3836p_19655) 4600128..4600337 - 210 WP_003486601.1 CsbD family protein -
XeaCFBP3836p_RS19660 (XeaCFBP3836p_19660) 4600565..4600699 - 135 WP_005914328.1 entericidin A/B family lipoprotein Toxin
XeaCFBP3836p_RS19665 (XeaCFBP3836p_19665) 4600774..4600926 - 153 WP_011348912.1 entericidin A/B family lipoprotein Antitoxin
XeaCFBP3836p_RS19670 (XeaCFBP3836p_19670) 4601033..4601956 - 924 WP_008576436.1 arginase -
XeaCFBP3836p_RS19675 (XeaCFBP3836p_19675) 4602277..4602728 + 452 Protein_3858 roadblock/LC7 domain-containing protein -
XeaCFBP3836p_RS19680 (XeaCFBP3836p_19680) 4602792..4603151 + 360 WP_003486613.1 hypothetical protein -
XeaCFBP3836p_RS19685 (XeaCFBP3836p_19685) 4603248..4604165 + 918 WP_008576439.1 hypothetical protein -
XeaCFBP3836p_RS19690 (XeaCFBP3836p_19690) 4604162..4604704 + 543 WP_003486615.1 GTPase -
XeaCFBP3836p_RS19695 (XeaCFBP3836p_19695) 4605175..4605855 + 681 WP_029820637.1 dTMP kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Entericidin A/B

(23-42)

Antitoxin

Entericidin A/B

(23-42)


Sequences

Toxin        


Download         Length: 45 a.a.        Molecular weight: 4459.32 Da        Isoelectric Point: 9.3487

>T197561 WP_005914328.1 NZ_CP072268:c4600699-4600565 [Xanthomonas euvesicatoria pv. alfalfae]
MKRAIVLLVLSMLSVGMLAGCNTVAGAGKDVQGAGEKVEDAARK

Download         Length: 135 bp

>T197561 NZ_CP096244:7252-7668 [Klebsiella pneumoniae subsp. pneumoniae]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 51 a.a.        Molecular weight: 5123.06 Da        Isoelectric Point: 8.2782

>AT197561 WP_011348912.1 NZ_CP072268:c4600926-4600774 [Xanthomonas euvesicatoria pv. alfalfae]
MKRLLTLMVLGLFSAGVMTGCNTVAGAGKDMQGAGDKVEKTAEKCSDGKC

Download         Length: 153 bp

>AT197561 NZ_CP096244:7025-7255 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G2W7U6

Antitoxin

Source ID Structure
AlphaFold DB A0A3G2W7I0

References