Detailed information of TA system TA197560

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 131653..132197
• Replicon: chromosome
• Accession: NZ_CP072268
• Organism: Xanthomonas euvesicatoria pv. alfalfae strain CFBP3836

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: XeaCFBP3836p_RS00485
• Protein ID: WP_234934393.1
• Coordinates: 131919..132197 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A7Z7EKF2
• Locus tag: XeaCFBP3836p_RS00480
• Protein ID: WP_029818122.1
• Coordinates: 131653..131910 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
XeaCFBP3836p_RS00465 (XeaCFBP3836p_00465)	126791..128254	-	1464	WP_029818118.1	ribonuclease H-like domain-containing protein	-
XeaCFBP3836p_RS00470 (XeaCFBP3836p_00470)	128251..130746	-	2496	WP_029818119.1	DEAD/DEAH box helicase	-
XeaCFBP3836p_RS00475 (XeaCFBP3836p_00475)	130924..131586	+	663	WP_029818121.1	hemolysin III family protein	-
XeaCFBP3836p_RS00480 (XeaCFBP3836p_00480)	131653..131910	+	258	WP_029818122.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
XeaCFBP3836p_RS00485 (XeaCFBP3836p_00485)	131919..132197	+	279	WP_234934393.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
XeaCFBP3836p_RS00495 (XeaCFBP3836p_00495)	132377..133276	-	900	WP_029818124.1	SDR family NAD(P)-dependent oxidoreductase	-
XeaCFBP3836p_RS00500 (XeaCFBP3836p_00500)	133336..134073	-	738	WP_029818125.1	SDR family oxidoreductase	-
XeaCFBP3836p_RS00505 (XeaCFBP3836p_00505)	134198..135109	+	912	WP_029818126.1	LysR family transcriptional regulator	-
XeaCFBP3836p_RS00510 (XeaCFBP3836p_00510)	135308..136018	+	711	WP_033837219.1	hypothetical protein	-
XeaCFBP3836p_RS00515 (XeaCFBP3836p_00515)	136240..136848	-	609	WP_008574046.1	NAD(P)H-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10514.14 Da
• Isoelectric Point: 10.5213

>T197560 WP_234934393.1 NZ_CP072268:131919-132197 [Xanthomonas euvesicatoria pv. alfalfae]
VPALADLDAIADYIAIDNAPAAAALVKRVFAHVEQLIEHPDSGSRPQELKRSRYRQIVEPPCRVFYRVDGQRIVVVHVMR
SERALRRNRLSR

Nucleotide

• Length: 279 bp

>T197560 NZ_CP096244:c6217-5912 [Klebsiella pneumoniae subsp. pneumoniae]
ATGCAGTTTAAGGTTTATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGACGGATGGTGATCCCGCTGGCCAGCGCCCGGCTGCTGTCGGATAAGGTTTCCCGTGAACTCTATCCGGTGG
TGCACATCGGGGATGAAAGCTACCGCCTGATGACCACGGACATGGCCAGCGTCACGTCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCAGCCACCGGGAAAATGACATCAAAAATGCGATAAACCTGATGTTCTGGGGAATTTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9632.12 Da
• Isoelectric Point: 8.6223

>AT197560 WP_029818122.1 NZ_CP072268:131653-131910 [Xanthomonas euvesicatoria pv. alfalfae]
MRTELVTTLKRQATELLAAAERDKEPILITQHGLPSAYLVDVASYERMQQRIALLEGIARGEMAVADGRTLSHEQAQQRM
ARWLK

Nucleotide

• Length: 258 bp

>AT197560 NZ_CP096244:c6437-6219 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAAGCAGCGCATCACTGTCACCATAGACAGCGACAGTTATCAGTTACTGAAATCCGCAGACGTCAATATCTCCGCCCT
GGTGAACAGGGCCATGCAGAATGAGGCCCGTCGTCTGCGTTCCGAACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCCG
AGGTTGCCCGCTTTATTGAGATGAACGGTTCATTCGCCGACGAAAACAGGGACTGGTGA

Structures

Antitoxin

• AlphaFold DB: A0A7Z7EKF2