Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 12790..13379 Replicon plasmid pXAG27.7119R
Accession NZ_CP072267
Organism Xanthomonas citri pv. glycines strain CFBP7119

Toxin (Protein)


Gene name pemK Uniprot ID Q32X98
Locus tag XcgCFBP7119R_RS24150 Protein ID WP_012477455.1
Coordinates 12790..13122 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID Q32X99
Locus tag XcgCFBP7119R_RS24155 Protein ID WP_012477454.1
Coordinates 13122..13379 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XcgCFBP7119R_RS24125 (XcgCFBP7119R_24125) 7973..8653 - 681 WP_012477460.1 hypothetical protein -
XcgCFBP7119R_RS24130 (XcgCFBP7119R_24130) 8667..9086 - 420 WP_012477459.1 hypothetical protein -
XcgCFBP7119R_RS24135 (XcgCFBP7119R_24135) 9374..9676 + 303 WP_012477458.1 hypothetical protein -
XcgCFBP7119R_RS24140 (XcgCFBP7119R_24140) 9678..11855 + 2178 WP_012477457.1 relaxase/mobilization nuclease domain-containing protein -
XcgCFBP7119R_RS24145 (XcgCFBP7119R_24145) 11883..12701 + 819 WP_012477456.1 hypothetical protein -
XcgCFBP7119R_RS24150 (XcgCFBP7119R_24150) 12790..13122 - 333 WP_012477455.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
XcgCFBP7119R_RS24155 (XcgCFBP7119R_24155) 13122..13379 - 258 WP_012477454.1 plasmid stable inheritance protein I Antitoxin
XcgCFBP7119R_RS24160 (XcgCFBP7119R_24160) 13645..13872 + 228 WP_012477437.1 hypothetical protein -
XcgCFBP7119R_RS24165 (XcgCFBP7119R_24165) 13869..14513 + 645 WP_012477436.1 recombinase family protein -
XcgCFBP7119R_RS24170 (XcgCFBP7119R_24170) 14580..15230 + 651 WP_012477435.1 ParA family protein -
XcgCFBP7119R_RS24175 (XcgCFBP7119R_24175) 15230..15484 + 255 WP_012477434.1 hypothetical protein -
XcgCFBP7119R_RS24180 (XcgCFBP7119R_24180) 15707..15865 + 159 WP_154666355.1 hypothetical protein -
XcgCFBP7119R_RS24185 (XcgCFBP7119R_24185) 15862..16668 + 807 WP_016851361.1 serine protease -
XcgCFBP7119R_RS24190 (XcgCFBP7119R_24190) 16734..17654 + 921 WP_012477431.1 replication protein RepA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..26620 26620


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11581.24 Da        Isoelectric Point: 9.1684

>T197559 WP_012477455.1 NZ_CP072267:c13122-12790 [Xanthomonas citri pv. glycines]
MERGDIYLVSLDPTSGHEQQGTRPVLIVSPGPFNRLTKTPVVLPITTGGNFARTAGFTVSLTGGGTKTTGVVRCDQPRAL
DIGSRNGRKLESVSAAITDEVMAKLATILE

Download         Length: 333 bp

>T197559 NZ_CP096243:c155376-154933 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAACAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
TGGGCACGCTATCGCGGCCGGCGCCGTCCTAGTGACGAACAATGTGAGAGAGTTTGAGCGGGTGCCGGGTCTGGTGCTGG
AAGACTGGGTGAAGAAAGCCGCTCTCTGCAGGGTAATTTCTTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 8951.34 Da        Isoelectric Point: 5.5491

>AT197559 WP_012477454.1 NZ_CP072267:c13379-13122 [Xanthomonas citri pv. glycines]
MHTTNLRKVGGSVMLAVPPALLDVLHIGAGAKVGLAVDNGRLVVEPHARPRYTLADLLAQCDASAELASEDREWLDAKPV
GGELL

Download         Length: 258 bp

>AT197559 NZ_CP096243:c155603-155373 [Klebsiella pneumoniae subsp. pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGCTCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z6Z9Y5

Antitoxin

Source ID Structure
AlphaFold DB A0A1D9EPT3

References