Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 5435143..5435810 Replicon chromosome
Accession NZ_CP072265
Organism Xanthomonas citri pv. glycines strain CFBP7119

Toxin (Protein)


Gene name vapC Uniprot ID M4U0C6
Locus tag XcgCFBP7119R_RS23490 Protein ID WP_005916679.1
Coordinates 5435394..5435810 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M4U000
Locus tag XcgCFBP7119R_RS23485 Protein ID WP_005916676.1
Coordinates 5435143..5435397 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XcgCFBP7119R_RS23460 (XcgCFBP7119R_23460) 5431315..5431458 + 144 WP_005916661.1 RNA 2'-phosphotransferase -
XcgCFBP7119R_RS23465 (XcgCFBP7119R_23465) 5431641..5432906 + 1266 WP_016849472.1 phospholipase D-like domain-containing protein -
XcgCFBP7119R_RS23470 (XcgCFBP7119R_23470) 5432932..5433459 - 528 WP_005916668.1 hypothetical protein -
XcgCFBP7119R_RS23475 (XcgCFBP7119R_23475) 5433698..5433904 + 207 WP_003489327.1 hypothetical protein -
XcgCFBP7119R_RS23480 (XcgCFBP7119R_23480) 5433891..5434997 + 1107 WP_005916674.1 type II toxin-antitoxin system RelE/ParE family toxin -
XcgCFBP7119R_RS23485 (XcgCFBP7119R_23485) 5435143..5435397 + 255 WP_005916676.1 Arc family DNA-binding protein Antitoxin
XcgCFBP7119R_RS23490 (XcgCFBP7119R_23490) 5435394..5435810 + 417 WP_005916679.1 type II toxin-antitoxin system VapC family toxin Toxin
XcgCFBP7119R_RS23495 (XcgCFBP7119R_23495) 5435932..5436204 - 273 WP_124632111.1 hypothetical protein -
XcgCFBP7119R_RS23500 (XcgCFBP7119R_23500) 5436217..5436477 - 261 WP_124632112.1 hypothetical protein -
XcgCFBP7119R_RS23505 (XcgCFBP7119R_23505) 5436734..5438353 + 1620 WP_016849230.1 alpha/beta hydrolase-fold protein -
XcgCFBP7119R_RS23510 (XcgCFBP7119R_23510) 5438457..5438855 - 399 WP_004429277.1 DUF2384 domain-containing protein -
XcgCFBP7119R_RS23515 (XcgCFBP7119R_23515) 5439171..5439602 + 432 WP_016849229.1 hypothetical protein -
XcgCFBP7119R_RS23520 (XcgCFBP7119R_23520) 5439631..5439861 - 231 WP_226690114.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-127)

Antitoxin

Arc-like DNA binding domain

(1-39)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14795.09 Da        Isoelectric Point: 5.6920

>T197558 WP_005916679.1 NZ_CP072265:5435394-5435810 [Xanthomonas citri pv. glycines]
VILLDTNVISELWRPQPNPQVVAWIDAQAVETLFLSVVTVAELRFGIAVMPKGRKRSTLHARLEGEVLPLFDGRLLAFDL
DASHAFAALASKARTAGLTLGRADAYIAATAAAQGLTVATRDTAPFEAMALDVINPWS

Download         Length: 417 bp

>T197558 NZ_CP096243:c102788-102318 [Klebsiella pneumoniae subsp. pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
TTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAACTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 8996.53 Da        Isoelectric Point: 11.3362

>AT197558 WP_005916676.1 NZ_CP072265:5435143-5435397 [Xanthomonas citri pv. glycines]
MPSFTVRNIPDDVHRAIRARAALHGRSTEAEIRAILELAAKPADRVKLGSLLVSIGRDAGLTAKEANAFDKLRGKAAIKP
IGLK

Download         Length: 255 bp

>AT197558 NZ_CP096243:c103228-102785 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAAAACATTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
CGTAGCGCTTCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGCGAATCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCGACCACGTTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGGATTATCCGCGTCATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAAGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAGACAGGAGCGTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M4U0C6

Antitoxin

Source ID Structure
AlphaFold DB A0A828YKJ0

References