Detailed information of TA system TA197556

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 99296..99840
• Replicon: chromosome
• Accession: NZ_CP072265
• Organism: Xanthomonas citri pv. glycines strain CFBP7119

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: XcgCFBP7119R_RS00430
• Protein ID: WP_016849692.1
• Coordinates: 99562..99840 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1D9ED60
• Locus tag: XcgCFBP7119R_RS00425
• Protein ID: WP_016849693.1
• Coordinates: 99296..99553 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
XcgCFBP7119R_RS00410 (XcgCFBP7119R_00410)	94403..95896	-	1494	WP_029995922.1	ribonuclease H-like domain-containing protein	-
XcgCFBP7119R_RS00415 (XcgCFBP7119R_00415)	95893..98388	-	2496	WP_016849694.1	DEAD/DEAH box helicase	-
XcgCFBP7119R_RS00420 (XcgCFBP7119R_00420)	98566..99228	+	663	WP_005912558.1	hemolysin III family protein	-
XcgCFBP7119R_RS00425 (XcgCFBP7119R_00425)	99296..99553	+	258	WP_016849693.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
XcgCFBP7119R_RS00430 (XcgCFBP7119R_00430)	99562..99840	+	279	WP_016849692.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
XcgCFBP7119R_RS00440 (XcgCFBP7119R_00440)	100028..100926	-	899	Protein_84	SDR family NAD(P)-dependent oxidoreductase	-
XcgCFBP7119R_RS00445 (XcgCFBP7119R_00445)	100985..101722	-	738	WP_016849691.1	SDR family oxidoreductase	-
XcgCFBP7119R_RS00450 (XcgCFBP7119R_00450)	101848..102759	+	912	WP_016849690.1	LysR family transcriptional regulator	-
XcgCFBP7119R_RS00455 (XcgCFBP7119R_00455)	102956..104029	-	1074	WP_026006953.1	ATP-grasp fold amidoligase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10429.03 Da
• Isoelectric Point: 10.1557

>T197556 WP_016849692.1 NZ_CP072265:99562-99840 [Xanthomonas citri pv. glycines]
VPALADLDAIADYIAIDNAPAAAALVKRVFAHVEQLIEHPDSGSRPQELKRSRYRQIVEPPCRVFYRVDGQRIVVVHIMR
SERALRGNRLSR

Nucleotide

• Length: 279 bp

>T197556 NZ_CP096242:c5382979-5382596 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTTGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGGTTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9674.20 Da
• Isoelectric Point: 9.8271

>AT197556 WP_016849693.1 NZ_CP072265:99296-99553 [Xanthomonas citri pv. glycines]
MRTELVTTLKRQATELLAAAERDKEPILITQHGLPSAYLVDVASYERMQQRIALLEGIARGEMAVAEGRTLSHEQARQRM
ARWLK

Nucleotide

• Length: 258 bp

>AT197556 NZ_CP096242:c5383221-5382979 [Klebsiella pneumoniae subsp. pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Structures

Antitoxin

• AlphaFold DB: A0A1D9ED60