Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 5206275..5206942 Replicon chromosome
Accession NZ_CP072263
Organism Xanthomonas citri pv. glycines CFBP 2526

Toxin (Protein)


Gene name vapC Uniprot ID M4U0C6
Locus tag XcgCFBP2526_RS22455 Protein ID WP_005916679.1
Coordinates 5206526..5206942 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M4U000
Locus tag XcgCFBP2526_RS22450 Protein ID WP_005916676.1
Coordinates 5206275..5206529 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XcgCFBP2526_RS22425 (XcgCFBP2526_22425) 5202447..5202590 + 144 WP_005916661.1 RNA 2'-phosphotransferase -
XcgCFBP2526_RS22430 (XcgCFBP2526_22430) 5202773..5204038 + 1266 WP_016849472.1 phospholipase D-like domain-containing protein -
XcgCFBP2526_RS22435 (XcgCFBP2526_22435) 5204064..5204591 - 528 WP_005916668.1 hypothetical protein -
XcgCFBP2526_RS22440 (XcgCFBP2526_22440) 5204830..5205036 + 207 WP_003489327.1 hypothetical protein -
XcgCFBP2526_RS22445 (XcgCFBP2526_22445) 5205023..5206129 + 1107 WP_005916674.1 type II toxin-antitoxin system RelE/ParE family toxin -
XcgCFBP2526_RS22450 (XcgCFBP2526_22450) 5206275..5206529 + 255 WP_005916676.1 Arc family DNA-binding protein Antitoxin
XcgCFBP2526_RS22455 (XcgCFBP2526_22455) 5206526..5206942 + 417 WP_005916679.1 type II toxin-antitoxin system VapC family toxin Toxin
XcgCFBP2526_RS22460 (XcgCFBP2526_22460) 5207064..5207336 - 273 WP_124632111.1 hypothetical protein -
XcgCFBP2526_RS22465 (XcgCFBP2526_22465) 5207349..5207609 - 261 WP_124632112.1 hypothetical protein -
XcgCFBP2526_RS22470 (XcgCFBP2526_22470) 5207866..5209485 + 1620 WP_016849230.1 alpha/beta hydrolase-fold protein -
XcgCFBP2526_RS22475 (XcgCFBP2526_22475) 5209589..5209987 - 399 WP_004429277.1 DUF2384 domain-containing protein -
XcgCFBP2526_RS22480 (XcgCFBP2526_22480) 5210303..5210734 + 432 WP_016849229.1 hypothetical protein -
XcgCFBP2526_RS22485 (XcgCFBP2526_22485) 5210763..5210993 - 231 WP_226690114.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-127)

Antitoxin

Arc-like DNA binding domain

(1-39)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14795.09 Da        Isoelectric Point: 5.6920

>T197554 WP_005916679.1 NZ_CP072263:5206526-5206942 [Xanthomonas citri pv. glycines CFBP 2526]
VILLDTNVISELWRPQPNPQVVAWIDAQAVETLFLSVVTVAELRFGIAVMPKGRKRSTLHARLEGEVLPLFDGRLLAFDL
DASHAFAALASKARTAGLTLGRADAYIAATAAAQGLTVATRDTAPFEAMALDVINPWS

Download         Length: 417 bp

>T197554 NZ_CP096242:c4745959-4745426 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCTGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 8996.53 Da        Isoelectric Point: 11.3362

>AT197554 WP_005916676.1 NZ_CP072263:5206275-5206529 [Xanthomonas citri pv. glycines CFBP 2526]
MPSFTVRNIPDDVHRAIRARAALHGRSTEAEIRAILELAAKPADRVKLGSLLVSIGRDAGLTAKEANAFDKLRGKAAIKP
IGLK

Download         Length: 255 bp

>AT197554 NZ_CP096242:c4746236-4745970 [Klebsiella pneumoniae subsp. pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M4U0C6

Antitoxin

Source ID Structure
AlphaFold DB A0A828YKJ0

References