Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 2934499..2935019 Replicon chromosome
Accession NZ_CP072251
Organism Bacteroides cellulosilyticus strain CL06T03C01

Toxin (Protein)


Gene name relE Uniprot ID A0A0P0FXI6
Locus tag INE78_RS10065 Protein ID WP_029427925.1
Coordinates 2934750..2935019 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A642Q1Y6
Locus tag INE78_RS10060 Protein ID WP_044153323.1
Coordinates 2934499..2934753 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INE78_RS10045 (INE78_02017) 2930187..2931260 + 1074 WP_060407791.1 hypothetical protein -
INE78_RS10050 (INE78_02018) 2931437..2933053 + 1617 WP_149919566.1 hypothetical protein -
INE78_RS10055 (INE78_02019) 2933342..2934364 + 1023 WP_007210324.1 DUF3871 family protein -
INE78_RS10060 (INE78_02020) 2934499..2934753 + 255 WP_044153323.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
INE78_RS10065 (INE78_02021) 2934750..2935019 + 270 WP_029427925.1 Txe/YoeB family addiction module toxin Toxin
INE78_RS10070 (INE78_02022) 2935324..2935911 + 588 WP_195507487.1 tyrosine-type recombinase/integrase -
INE78_RS10075 (INE78_02024) 2936975..2937535 + 561 WP_195507486.1 hypothetical protein -
INE78_RS10080 (INE78_02025) 2937635..2938036 + 402 WP_211480345.1 hypothetical protein -
INE78_RS10085 (INE78_02026) 2938052..2938552 + 501 WP_195507484.1 hypothetical protein -
INE78_RS10090 (INE78_02027) 2938556..2938957 + 402 WP_195507483.1 lipocalin family protein -
INE78_RS10095 (INE78_02028) 2938954..2939184 + 231 Protein_1993 penicillin-binding protein -
INE78_RS10105 (INE78_02029) 2939650..2939937 - 288 WP_007210331.1 UpxY family transcription antiterminator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10919.78 Da        Isoelectric Point: 10.1450

>T197551 WP_029427925.1 NZ_CP072251:2934750-2935019 [Bacteroides cellulosilyticus]
MKVIFTPLAMEQWEYWKKTNPNIAKRIKRILLDIREHPYTGIAKPEPLKYDLMGKWSRRINEEHRIIYSVNDDRVEIDIL
SMRYHYSKK

Download         Length: 270 bp

>T197551 NZ_CP096242:2072111-2072213 [Klebsiella pneumoniae subsp. pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9419.54 Da        Isoelectric Point: 4.1357

>AT197551 WP_044153323.1 NZ_CP072251:2934499-2934753 [Bacteroides cellulosilyticus]
MRTANYTDLRANLKGYIDSVIDDYDTVIINRGNGKGVVMISLDEYNSLKETEYIMSSPETMAAIRQGEEDIKNGKGIEVN
LDEL

Download         Length: 255 bp

>AT197551 NZ_CP096242:c2072220-2072075 [Klebsiella pneumoniae subsp. pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0P0FXI6

Antitoxin

Source ID Structure
AlphaFold DB A0A642Q1Y6

References