Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1847725..1848340 Replicon chromosome
Accession NZ_CP072251
Organism Bacteroides cellulosilyticus strain CL06T03C01

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag INE78_RS06415 Protein ID WP_195507047.1
Coordinates 1848080..1848340 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag INE78_RS06410 Protein ID WP_195507048.1
Coordinates 1847725..1848066 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INE78_RS06395 (INE78_01288) 1843380..1845002 - 1623 WP_007216882.1 tetratricopeptide repeat protein -
INE78_RS06400 (INE78_01289) 1845099..1845704 + 606 WP_195507050.1 ribonuclease HII -
INE78_RS06405 (INE78_01290) 1845705..1847261 - 1557 WP_229098627.1 PQQ-like beta-propeller repeat protein -
INE78_RS06410 (INE78_01291) 1847725..1848066 - 342 WP_195507048.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
INE78_RS06415 (INE78_01292) 1848080..1848340 - 261 WP_195507047.1 type II toxin-antitoxin system HicA family toxin Toxin
INE78_RS06420 (INE78_01293) 1848603..1848992 - 390 WP_195507046.1 helix-turn-helix transcriptional regulator -
INE78_RS06425 (INE78_01294) 1849261..1849908 + 648 WP_195507045.1 hypothetical protein -
INE78_RS06430 (INE78_01295) 1849913..1850776 + 864 WP_195507044.1 hypothetical protein -
INE78_RS06435 (INE78_01296) 1850798..1853338 + 2541 WP_195507043.1 carboxypeptidase regulatory-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-79)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 9980.60 Da        Isoelectric Point: 10.2532

>T197550 WP_195507047.1 NZ_CP072251:c1848340-1848080 [Bacteroides cellulosilyticus]
MSTKEKLIDRFCKMPKDFTYEETLKVLSAFGYNEHNKGATSGSRVRFKNEQTGQYIDIHKPHPGSIMKAWMMKAIYQHLK
SNGLIK

Download         Length: 261 bp

>T197550 NZ_CP096242:797925-798335 [Klebsiella pneumoniae subsp. pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12494.14 Da        Isoelectric Point: 4.7009

>AT197550 WP_195507048.1 NZ_CP072251:c1848066-1847725 [Bacteroides cellulosilyticus]
MDYLEYKGYKGSVEYSKADNCLFGKVLGMSKDLILYEGNTIDELRADFEAGIENYLEGCLADGVEPRKPYSGTLNIRISP
DVHGRIAALAQEAGTTINGYIKQALENQLKMAH

Download         Length: 342 bp

>AT197550 NZ_CP096242:797678-797944 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References