Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 198795..199408 Replicon chromosome
Accession NZ_CP072231
Organism Parabacteroides distasonis strain CL06T03C10

Toxin (Protein)


Gene name hicA Uniprot ID E1YXK9
Locus tag INE86_RS00745 Protein ID WP_005866745.1
Coordinates 198795..199055 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID E1YXL0
Locus tag INE86_RS00750 Protein ID WP_005866743.1
Coordinates 199067..199408 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INE86_RS00730 (INE86_00149) 194486..195892 - 1407 WP_005866749.1 di-heme oxidoredictase family protein -
INE86_RS00735 (INE86_00150) 195910..197121 - 1212 WP_008780678.1 imelysin family protein -
INE86_RS00740 (INE86_00151) 197152..198465 - 1314 WP_005861166.1 porin -
INE86_RS00745 (INE86_00152) 198795..199055 + 261 WP_005866745.1 type II toxin-antitoxin system HicA family toxin Toxin
INE86_RS00750 (INE86_00153) 199067..199408 + 342 WP_005866743.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
INE86_RS00755 199742..200395 - 654 Protein_144 transcriptional regulator -
INE86_RS00760 (INE86_00156) 200411..200680 - 270 WP_211744647.1 hypothetical protein -
INE86_RS22445 201292..201429 - 138 WP_249932014.1 hypothetical protein -
INE86_RS00770 (INE86_00157) 202111..203658 + 1548 WP_211744648.1 arylsulfatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-79)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10036.60 Da        Isoelectric Point: 10.0271

>T197547 WP_005866745.1 NZ_CP072231:198795-199055 [Parabacteroides distasonis]
MGSKEKLIERFCKLPKDFTYEETLKLLSSYGYNEHNKGATSGSRVRFKNEQTGQYIDIHKPHPGSIMKEWMMKAIYQHLK
SNGLIK

Download         Length: 261 bp

>T197547 NZ_CP096240:c6153-5848 [Klebsiella pneumoniae subsp. pneumoniae]
ATGCAGTTTAAGGTTTATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGACGGATGGTGATCCCGCTGGCCAGCGCCCGGCTGCTGTCGGATAAGGTTTCCCGTGAACTCTATCCGGTGG
TGCACATCGGGGATGAAAGCTACCGCCTGATGACCACGGACATGGCCAGCGTCACGTCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCAGCCACCGGGAAAATGACATCAAAAATGCGATAAACCTGATGTTCTGGGGAATTTGA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12391.06 Da        Isoelectric Point: 4.8780

>AT197547 WP_005866743.1 NZ_CP072231:199067-199408 [Parabacteroides distasonis]
MDYLEYKGYKGSVEYSKADNCLCGKVLGMSKDLILYEGNTIDELRADFEAGVESYLAGCLADGVEPRKPYSGTLNIRISP
EIHSRIAALAQEAGTTINGYIKQALENQLKLAH

Download         Length: 342 bp

>AT197547 NZ_CP096240:c6373-6155 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAAGCAGCGCATCACTGTCACCATAGACAGCGACAGTTATCAGTTACTGAAATCCGCAGACGTCAATATCTCCGCCCT
GGTGAACAGGGCCATGCAGAATGAGGCCCGTCGTCTGCGTTCCGAACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCCG
AGGTTGCCCGCTTTATTGAGATGAACGGTTCATTCGCCGACGAAAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A496DRY4

Antitoxin

Source ID Structure
AlphaFold DB A0A069SEG1

References