Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 43414..44030 Replicon chromosome
Accession NZ_CP072203
Organism Gordonia polyisoprenivorans strain R9

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag J6U32_RS00230 Protein ID WP_208793031.1
Coordinates 43623..44030 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag J6U32_RS00225 Protein ID WP_208793030.1
Coordinates 43414..43626 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J6U32_RS00195 (J6U32_00195) 39622..40338 + 717 WP_208793025.1 helix-turn-helix domain-containing protein -
J6U32_RS00200 (J6U32_00200) 40369..40620 - 252 WP_244332431.1 hypothetical protein -
J6U32_RS00205 (J6U32_00205) 40686..41114 - 429 WP_244332433.1 hypothetical protein -
J6U32_RS00210 (J6U32_00210) 41167..41526 - 360 WP_208793027.1 hypothetical protein -
J6U32_RS00215 (J6U32_00215) 41665..42834 + 1170 WP_208793028.1 LLM class flavin-dependent oxidoreductase -
J6U32_RS00220 (J6U32_00220) 42878..43330 + 453 WP_208793029.1 hypothetical protein -
J6U32_RS00225 (J6U32_00225) 43414..43626 + 213 WP_208793030.1 CopG family transcriptional regulator Antitoxin
J6U32_RS00230 (J6U32_00230) 43623..44030 + 408 WP_208793031.1 PIN domain-containing protein Toxin
J6U32_RS00235 (J6U32_00235) 44113..46452 - 2340 WP_208793032.1 endopeptidase La -
J6U32_RS00240 (J6U32_00240) 46670..47341 - 672 WP_208793033.1 alpha/beta hydrolase-fold protein -
J6U32_RS00245 (J6U32_00245) 47447..47890 - 444 WP_208793034.1 DUF4186 domain-containing protein -
J6U32_RS00250 (J6U32_00250) 47989..48507 - 519 WP_280118990.1 phenolic acid decarboxylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-118)

Antitoxin

Ribbon-helix-helix protein, CopG

(4-40)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14613.66 Da        Isoelectric Point: 4.4922

>T197515 WP_208793031.1 NZ_CP072203:43623-44030 [Gordonia polyisoprenivorans]
VILDTSALLAYFDSAEPQHSAVAEIIESHSGPLVISPFVIAELDYLLLTRHGTRAEQVVLSELTSGAWELASMTRSRIVT
ATAIVERYSDIPIGVTDASNIVLADAYQTSLIATLDHRHFSILRLMDGSPPTIVP

Download         Length: 408 bp

>T197515 NZ_CP096230:c5373571-5373188 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTTGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGGTTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7765.83 Da        Isoelectric Point: 4.8409

>AT197515 WP_208793030.1 NZ_CP072203:43414-43626 [Gordonia polyisoprenivorans]
MAKTTLYLPDDLKRAIELEARRRSISEAEVVREALRAALDGQKPRPRGGLFVGSEPIAERAEELLDGFGE

Download         Length: 213 bp

>AT197515 NZ_CP096230:c5373813-5373571 [Klebsiella pneumoniae subsp. pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References