Detailed information of TA system TA197510

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 5275317..5276998
• Replicon: chromosome
• Accession: NZ_CP072200
• Organism: Klebsiella pneumoniae strain B5055

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: J2XCI1
• Locus tag: J6T75_RS25590
• Protein ID: WP_004146663.1
• Coordinates: 5275317..5276234 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: W9BJR4
• Locus tag: J6T75_RS25595
• Protein ID: WP_016531766.1
• Coordinates: 5276240..5276998 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J6T75_RS25570 (J6T75_25510)	5270623..5272143	+	1521	WP_004210021.1	sugar ABC transporter ATP-binding protein	-
J6T75_RS25575 (J6T75_25515)	5272140..5273138	+	999	WP_002885172.1	ribose ABC transporter permease	-
J6T75_RS25580 (J6T75_25520)	5273169..5274110	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
J6T75_RS25585 (J6T75_25525)	5274185..5275192	+	1008	WP_004221949.1	carbohydrate kinase family protein	-
J6T75_RS25590 (J6T75_25530)	5275317..5276234	-	918	WP_004146663.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
J6T75_RS25595 (J6T75_25535)	5276240..5276998	-	759	WP_016531766.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
J6T75_RS25600 (J6T75_25540)	5277084..5277812	-	729	WP_004177810.1	response regulator transcription factor	-
J6T75_RS25605 (J6T75_25545)	5278085..5280232	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
J6T75_RS25610 (J6T75_25550)	5280462..5281148	+	687	WP_004151733.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34659.10 Da
• Isoelectric Point: 5.4707

>T197510 WP_004146663.1 NZ_CP072200:c5276234-5275317 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T197510 NZ_CP096230:2009668-2009770 [Klebsiella pneumoniae subsp. pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28476.86 Da
• Isoelectric Point: 10.1683

>AT197510 WP_016531766.1 NZ_CP072200:c5276998-5276240 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFRGFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT197510 NZ_CP096230:c2009777-2009632 [Klebsiella pneumoniae subsp. pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Structures

Toxin

• AlphaFold DB: J2XCI1

Antitoxin

• AlphaFold DB: W9BJR4